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I3909

Ionomycin calcium salt 钙盐

Name: Ionomycin calcium salt 钙盐
Brand: SIGMA

Ready Made Solution, from Streptomyces conglobatus, 1 mM in DMSO

别名:

钙离子载体离子霉素

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关于此项目

经验公式（希尔记法）:

C₄₁H₇₀CaO₉

化学文摘社编号:

56092-82-1

分子量:

747.07

NACRES:

NA.85

PubChem Substance ID:

329815372

UNSPSC Code:

51102829

EC Number:

200-664-3

MDL number:

MFCD00083634

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biological source

Streptomyces conglobatus

Quality Level

300

assay

≥98% (HPLC)

shelf life

2 yr

storage condition

(Tightly closed. )

concentration

1 mM in DMSO

color

colorless

mp

18.4 °C

solubility

DMSO: 1 mM

antibiotic activity spectrum

Gram-positive bacteria

mode of action

cell membrane | interferes

shipped in

wet ice

storage temp.

−20°C

SMILES string

C[C@@H]1CCC(=O)O[Ca]OC(=CC(=O)[C@@H](C)C[C@@H](C)C1)[C@H](C)C[C@H](C)C\C=C\[C@@H](C)[C@@H](O)[C@@H](C)[C@@H](O)C[C@@H]2CC[C@](C)(O2)[C@H]3CC[C@](C)(O3)[C@@H](C)O

InChI

1S/C41H72O9.Ca/c1-25(21-29(5)34(43)24-35(44)30(6)22-27(3)20-26(2)14-15-38(46)47)12-11-13-28(4)39(48)31(7)36(45)23-33-16-18-41(10,49-33)37-17-19-40(9,50-37)32(8)42;/h11,13,24-33,36-37,39,42-43,45,48H,12,14-23H2,1-10H3,(H,46,47);/q;+2/p-2/b13-11+,34-24-;/t25-,26-,27+,28-,29-,30+,31+,32-,33+,36+,37-,39-,40+,41+;/m1./s1

InChI key

WKRWUYKLUMMAKG-WYGBAUISSA-L

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General description

离子霉素(Ionomycin)是一种由密团链霉菌(Streptomyces conglobatus)产生的钙离子载体，可穿过细胞膜运输钙离子。常作为一种高效工具用以研究钙离子介导信号转导及钙离子在各种生物过程中的作用，包括细胞激活、分泌、增殖和凋亡。

离子霉素在细胞生物学研究中常用于快速可控地提高胞内钙离子浓度。进而可研究钙离子信号转导通路的下游效应，例如酶激活、激素释放和基因表达变化。离子霉素也用于研究钙离子在某些细胞过程中的作用，包括细胞死亡、免疫细胞激活和肌肉收缩。具体上，比如离子霉素可用于诱导癌细胞凋亡、研究T细胞激活、探索肌肉收缩中的钙作用。

Application

离子霉素用途：

研究钙离子介导信号转导及钙离子在各种生物过程中的作用
研究细胞内钙浓度、钙依赖性酶和钙内流引起的细胞反应
在细胞生物学研究中快速可控地提高胞内钙离子浓度
联合荧光钙离子指示剂或蛋白激酶激活剂等物质研究某些细胞机制和信号通路

离子霉素已用于：

诱发中枢性脱髓鞘
抑制牛肾上腺TREK-1通道
调节人成熟B细胞的细胞分裂

Biochem/physiol Actions

比A23187更有效地作为Ca²⁺的移动离子载体的Ca²⁺ 离子载体

离子霉素是一种离子渗透型抗生素，可与Pb2+和Ca2+结合，用作两种阳离子的有效移动载体。

作用机制：促进钙离子(Ca2+)跨生物膜运输

抗菌谱：对革兰氏阳性菌有抗菌活性。

离子霉素是一种离子渗透型抗生素，可与Pb²⁺和Ca²⁺结合，可用作两种阳离子的有效动态载体。离子霉素作为C²⁺的动态载体比A23187更有效。它是非荧光的。它用于研究跨生物膜的Ca²⁺转运，并诱导胚胎皮质神经元的凋亡性变性。

Features and Benefits

成品溶液，无需制备
钙离子信号转导及钙在各种生物过程中作用的高效研究工具
快速可控地调节胞内钙浓度
功能多样，广泛用于细胞生物学研究

Other Notes

如需了解生化试剂系列的更多信息，请填写此表。

存储类别

10 - Combustible liquids

wgk

WGK 1

flash_point_f

188.6 °F - closed cup

flash_point_c

87 °C - closed cup

ppe

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

0000536348

0000431187

0000421433

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Regulation of cell division of mature B cells by ionomycin and phorbol ester.

K M Kim et al.

Journal of immunology (Baltimore, Md. : 1950), 148(6), 1797-1803 (1992-03-15)

The growth of a human B lymphoma cell line B104, an experimental model for mature B cells, was inhibited by ionomycin but not 12-O-tetradecanoylphorbol-13-acetate (TPA). Ionomycin inhibited B104 cells from entering into the M phase of the cell cycle without

Central demyelination induced in vivo by the calcium ionophore ionomycin.

K J Smith et al.

Brain : a journal of neurology, 117 ( Pt 6), 1351-1356 (1994-12-01)

The effects of injecting the calcium-selective ionophore, ionomycin, into myelinated tracts in the dorsal columns of adult rat spinal cords were examined electron microscopically. In vivo, ionomycin induced a primary vesicular demyelination, together with a variable degree of axonal degeneration

A granular variant of CD63 is a regulator of repeated human mast cell degranulation.

Thorsten Schäfer et al.

Allergy, 65(10), 1242-1255 (2010-03-27)

Mast cells are secretory immune cells whose degranulation can provoke acute allergic reactions. It is presently unclear, however, whether an individual mast cell can repeatedly degranulate or turns dysfunctional after a single antigen stimulus. This work thus aims to better

Calcium-dependent inhibition of adrenal TREK-1 channels by angiotensin II and ionomycin.

John J Enyeart et al.

American journal of physiology. Cell physiology, 301(3), C619-C629 (2011-05-27)

Bovine adrenocortical cells express bTREK-1 K(+) (bovine KCNK2) channels that are inhibited by ANG II through a Gq-coupled receptor by separate Ca(2+) and ATP hydrolysis-dependent signaling pathways. Whole cell and single patch clamp recording from adrenal zona fasciculata (AZF) cells

Effects of non-euphoric plant cannabinoids on muscle quality and performance of dystrophic mdx mice.

Fabio Arturo Iannotti et al.

British journal of pharmacology, 176(10), 1568-1584 (2018-08-04)

Duchenne muscular dystrophy (DMD), caused by dystrophin deficiency, results in chronic inflammation and irreversible skeletal muscle degeneration. Moreover, the associated impairment of autophagy greatly contributes to the aggravation of muscle damage. We explored the possibility of using non-euphoric compounds present

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货号	GTIN
I3909-1ML	04061833856444

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