I4011
胰岛素 来源于牛胰腺
Hybri-Max™, powder, suitable for hybridoma
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关于此项目
经验公式（希尔记法）:
C254H377N65O75S6
CAS Number:
分子量:
5733.49
EC 号:
MDL编号:
UNSPSC代码:
12352209
NACRES:
NA.77
生物来源
bovine
质量水平
等级
Hybri-Max™
表单
powder
效能
≥20 USP units per mg (dry basis)
技术
cell culture | hybridoma: suitable
杂质
endotoxin, tested
溶解性
acidified water, pH 2.0: 2 mg/mL
痕量阳离子
Zn: ≤1.0% (dry basis)
UniProt登记号
运输
ambient
储存温度
−20°C
InChI key
IXIBAKNTJSCKJM-BUBXBXGNSA-N
基因信息
bovine ... INS(280829)
cow ... INS(280829)
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一般描述
The insulin gene is mapped to human chromosome 11p15.5.
应用
Insulin from bovine pancreas has been used in endometrium cell culture. It has also been used to perform insulin tolerance test and to study the effect of protein undernutrition in laying hens.
Insulin from bovine pancreas was used during experimental design and treatments. Experimental animals (like cow) were infused with bovine insulin to decrease blood glucose to a constant level.
生化/生理作用
由胰岛β-细胞所产生的二链多肽激素。其分子量为~5800 Da。α链和β链是由两个链间二硫键所连接的。α链含有一个链间二硫键。胰岛素可调节细胞对葡萄糖、氨基酸和脂肪酸的摄取、利用和储存，并抑制糖原、蛋白质和脂肪的分解。
Abnormal insulin secretion or function leads to diabetes mellitus, obesity and other carbohydrate metabolism disorders. The biological effects of insulin are mediated by insulin receptor (glycoprotein) and it integrates major signaling pathways.
其他说明
InChI: 1S/C254H377N65O75S6/c1-29-131(24)205(312-192(334)103-256)250(389)317-204(130(22)23)246(385)287-158(74-81-199(344)345)216(355)281-155(70-77-188(260)330)220(359)307-183-116-399-400-117-184-242(381)305-177(110-321)238(377)293-161(87-122(6)7)223(362)294-167(94-139-52-60-145(324)61-53-139)226(365)282-153(68-75-186(258)328)217(356)289-160(86-121(4)5)221(360)284-157(73-80-198(342)343)219(358)301-173(100-189(261)331)233(372)297-169(96-141-56-64-147(326)65-57-141)229(368)308-182(241(380)303-175(253(393)394)102-191(263)333)115-398-396-113-180(212(351)270-106-193(335)277-152(71-78-196(338)339)215(354)280-150(50-41-83-268-254(264)265)210(349)269-107-194(336)278-165(92-137-45-35-31-36-46-137)225(364)296-166(93-138-47-37-32-38-48-138)228(367)298-170(97-142-58-66-148(327)67-59-142)236(375)318-206(135(28)323)251(390)319-84-42-51-185(319)244(383)285-151(49-39-40-82-255)213(352)276-134(27)252(391)392)310-248(387)202(128(18)19)315-234(373)163(89-124(10)11)291-227(366)168(95-140-54-62-146(325)63-55-140)295-222(361)159(85-120(2)3)288-207(346)132(25)274-214(353)156(72-79-197(340)341)286-245(384)201(127(16)17)314-235(374)164(90-125(12)13)292-231(370)172(99-144-105-267-119-273-144)300-237(376)176(109-320)279-195(337)108-271-211(350)179(112-395-397-114-181(309-243(183)382)240(379)275-133(26)208(347)304-178(111-322)239(378)316-203(129(20)21)249(388)311-184)306-224(363)162(88-123(8)9)290-230(369)171(98-143-104-266-118-272-143)299-218(357)154(69-76-187(259)329)283-232(371)174(101-190(262)332)302-247(386)200(126(14)15)313-209(348)149(257)91-136-43-33-30-34-44-136/h30-38,43-48,52-67,104-105,118-135,149-185,200-206,320-327H,29,39-42,49-51,68-103,106-117,255-257H2,1-28H3,(H2,258,328)(H2,259,329)(H2,260,330)(H2,261,331)(H2,262,332)(H2,263,333)(H,266,272)(H,267,273)(H,269,349)(H,270,351)(H,271,350)(H,274,353)(H,275,379)(H,276,352)(H,277,335)(H,278,336)(H,279,337)(H,280,354)(H,281,355)(H,282,365)(H,283,371)(H,284,360)(H,285,383)(H,286,384)(H,287,385)(H,288,346)(H,289,356)(H,290,369)(H,291,366)(H,292,370)(H,293,377)(H,294,362)(H,295,361)(H,296,364)(H,297,372)(H,298,367)(H,299,357)(H,300,376)(H,301,358)(H,302,386)(H,303,380)(H,304,347)(H,305,381)(H,306,363)(H,307,359)(H,308,368)(H,309,382)(H,310,387)(H,311,388)(H,312,334)(H,313,348)(H,314,374)(H,315,373)(H,316,378)(H,317,389)(H,318,375)(H,338,339)(H,340,341)(H,342,343)(H,344,345)(H,391,392)(H,393,394)(H4,264,265,268)/t131-,132-,133-,134-,135+,149-,150-,151-,152-,153-,154-,155-,156-,157-,158-,159-,160-,161-,162-,163-,164-,165-,166-,167-,168-,169-,170-,171-,172-,173-,174-,175-,176-,177-,178-,179-,180-,181-,182-,183-,184-,185-,200-,201-,202-,203-,204-,205-,206-/m0/s1
法律信息
Hybri-Max is a trademark of Sigma-Aldrich Co. LLC
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
法规信息
新产品
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Expression of glucocorticoid receptor alpha and its regulation in the bovine endometrium: Possible role in cyclic prostaglandin F2alpha production
Kuse M, et al.
Journal of Reproduction and Development, 59(4), 346-352 (2013)
Human longevity and 11p15. 5: a study in 1321 centenarians
Lescai F, et al.
European Journal of Human Genetics, 17(11), 1515-1515 (2009)
Expression of VEGF and its receptors in the bovine endometrium throughout the estrous cycle: effects of VEGF on prostaglandin production in endometrial cells
Tasak Y, et al.
Journal of Reproduction and Development, 56(2), 223-229 (2010)
Effects of nutritional programing on growth and metabolism caused by albumen removal in an avian model
Willems E, et al.
The Journal of Endocrinology, 225(2), 89-100 (2015)
M C M B Vernay et al.
Journal of dairy science, 95(5), 2540-2549 (2012-05-01)
The metabolic load during periods of high milk production in dairy cows causes a variety of changes of metabolite blood concentrations including dramatically decreased glucose levels. These changes supposedly impair the immune system. The goal of this study was, therefore
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