I4269
IL-4 human
≥98% (SDS-PAGE), recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture
别名:
IL-4, hIL-4
产品名称
白细胞介素4 人, IL-4, recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture
biological source
human
recombinant
expressed in E. coli
assay
≥98% (SDS-PAGE)
form
lyophilized powder
potency
≤0.400 ng/mL EC50
quality
endotoxin tested
mol wt
14.9 kDa (containing 129 amino acid residues)
packaging
pkg of 5 and 50 μg
technique(s)
cell culture | mammalian: suitable
impurities
≤1.000 EU/μg
color
white
UniProt accession no.
storage temp.
−20°C
Quality Level
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Analysis Note
通过剂量依赖性刺激人TF-1细胞的增殖来测量生物活性。
Application
淋巴因子对免疫活性细胞的生长和分化具有明显的影响，抑制 VEGF和βFGF 诱导的血管生成。
General description
白细胞介素-4（IL-4）是一种多效细胞因子，可调节多种 T细胞和B细胞反应，包括将初始 T细胞分化为TH2 表型，促进 B细胞增殖、抗体同种型转换和其他 TH2细胞因子（包括IL-5和IL-9）的表达。1,2 IL-4在过敏性炎症和哮喘的发生中起关键作用。3
IL-4 与两种不同的受体结合；I型受体，由IL-4Rα 链和常见 γ 链组成的异二聚体，γc，和II型受体，IL-4Rα和IL-13Rα的异二聚体。4
天然存在的IL-4分子质量为12-20 kDa。重组人IL-4是含有129个氨基酸残基的14.9kDa蛋白质。人和小鼠 IL-4 具有50％的氨基酸序列同源性，但它们的生物学作用是物种特异性的。5
IL-4 与两种不同的受体结合；I型受体，由IL-4Rα 链和常见 γ 链组成的异二聚体，γc，和II型受体，IL-4Rα和IL-13Rα的异二聚体。4
天然存在的IL-4分子质量为12-20 kDa。重组人IL-4是含有129个氨基酸残基的14.9kDa蛋白质。人和小鼠 IL-4 具有50％的氨基酸序列同源性，但它们的生物学作用是物种特异性的。5
Physical form
从无菌过滤溶液中冻干。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
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商品
Interleukins, released from leukocytes, include IL-1β playing crucial roles in inflammation, immune responses, and anti-tumor immunity.
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