I4401
干扰素-αA/D 人
≥95%, recombinant, expressed in E. coli, buffered aqueous solution, suitable for cell culture
别名:
IFN-αA/D
产品名称
干扰素-αA/D 人, ≥95%, recombinant, expressed in E. coli, buffered aqueous solution, suitable for cell culture
biological source
human
recombinant
expressed in E. coli
assay
≥95%
form
buffered aqueous solution
mol wt
19 kDa
packaging
pkg of 100K units
technique(s)
cell culture | mammalian: suitable
impurities
endotoxin, tested
color
colorless
UniProt accession no.
shipped in
dry ice
storage temp.
−70°C
Quality Level
Gene Information
human ... IFNA2(3440)
Analysis Note
在细胞病变效应抑制试验中，使用含有水泡性口炎病毒（VSV）的MDBK细胞测定生物活性。用1单位/ml干扰素可产生50%的细胞病变效应。单位是根据人干扰素αA的NIH国际标准参考确定的。
Application
已使用人干扰素-αA/D：
- 用于鉴定冠状病毒复制酶抑制剂
- 与ACH-806[1-（4-戊氧基-3-三氟甲基苯基）-3-（吡啶-3-羰基）硫脲]结合以研究对丙型肝炎病毒（HCV）复制的影响
- 与维生素D结合用于检查细胞培养物中HCV蛋白生成的减少
Biochem/physiol Actions
干扰素-αA/D（Bg/II），也称为通用I型干扰素，是一种跨越物种屏障的α干扰素杂种。Bg/II表示由重组人干扰素αA和αD构建该杂种的限制性酶切位点。干扰素-αA/D 已被证明对许多哺乳动物细胞具有活性。它可以替代人，猴，小鼠，牛，大鼠，猫，狗，兔，绵羊，山羊，马，猪或仓鼠I型干扰素（α，β，ω 和τ）。I型干扰素是由白细胞（α亚型），成纤维细胞（β亚型），淋巴细胞（ω亚型）和反刍动物胚胎（τ亚型）产生的165-172个氨基酸蛋白的密切相关家族。该细胞因子具有抗病毒、抗增殖、免疫调节和促炎活性。
该细胞因子具有抗病毒、抗增殖、免疫调节和促炎活性。
Physical form
磷酸盐缓冲盐水溶液，含有 1 mg/ml牛血清白蛋白。
存储类别
10 - Combustible liquids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves
法规信息
常规特殊物品
低风险生物材料
此项目有
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