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生物来源
human
质量水平
重组
expressed in E. coli
方案
≥95%
表单
buffered aqueous solution
分子量
19 kDa
包装
pkg of 100K units
技术
cell culture | mammalian: suitable
杂质
endotoxin, tested
颜色
colorless
UniProt登记号
运输
dry ice
储存温度
−70°C
基因信息
human ... IFNA2(3440)
应用
已使用人干扰素-αA/D：
- 用于鉴定冠状病毒复制酶抑制剂
- 与ACH-806[1-（4-戊氧基-3-三氟甲基苯基）-3-（吡啶-3-羰基）硫脲]结合以研究对丙型肝炎病毒（HCV）复制的影响
- 与维生素D结合用于检查细胞培养物中HCV蛋白生成的减少
生化/生理作用
干扰素-αA/D（Bg/II），也称为通用I型干扰素，是一种跨越物种屏障的α干扰素杂种。Bg/II表示由重组人干扰素αA和αD构建该杂种的限制性酶切位点。干扰素-αA/D 已被证明对许多哺乳动物细胞具有活性。它可以替代人，猴，小鼠，牛，大鼠，猫，狗，兔，绵羊，山羊，马，猪或仓鼠I型干扰素（α，β，ω 和τ）。I型干扰素是由白细胞（α亚型），成纤维细胞（β亚型），淋巴细胞（ω亚型）和反刍动物胚胎（τ亚型）产生的165-172个氨基酸蛋白的密切相关家族。该细胞因子具有抗病毒、抗增殖、免疫调节和促炎活性。
该细胞因子具有抗病毒、抗增殖、免疫调节和促炎活性。
外形
磷酸盐缓冲盐水溶液，含有 1 mg/ml牛血清白蛋白。
分析说明
在细胞病变效应抑制试验中，使用含有水泡性口炎病毒（VSV）的MDBK细胞测定生物活性。用1单位/ml干扰素可产生50%的细胞病变效应。单位是根据人干扰素αA的NIH国际标准参考确定的。
储存分类代码
10 - Combustible liquids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves
法规信息
常规特殊物品
含少量动物源组分生物产品
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Pathompong Bowornruangrit et al.
Medical sciences (Basel, Switzerland), 10(1) (2022-03-25)
Autophagy is a known mechanism of cells under internal stress that regulates cellular function via internal protein recycling and the cleaning up of debris, leading to healthy live cells. However, the stimulation of autophagy by external factors such as chemical
C Lauber et al.
Genes and immunity, 16(6), 414-421 (2015-06-13)
The IFNL4 gene is negatively associated with spontaneous and treatment-induced clearance of hepatitis C virus infection. The activity of IFNλ4 has an important causal role in the pathogenesis, but the molecular details are not fully understood. One possible reason for
Guido Wollmann et al.
Journal of virology, 89(13), 6711-6724 (2015-04-17)
High-grade tumors in the brain are among the deadliest of cancers. Here, we took a promising oncolytic virus, vesicular stomatitis virus (VSV), and tested the hypothesis that the neurotoxicity associated with the virus could be eliminated without blocking its oncolytic
Tobias Hertzig et al.
The Journal of general virology, 85(Pt 6), 1717-1725 (2004-05-29)
A previously unknown coronavirus (CoV) is the aetiological agent causing severe acute respiratory syndrome (SARS), for which an effective antiviral treatment is urgently needed. To enable the rapid and biosafe identification of coronavirus replicase inhibitors, we have generated a non-cytopathic
Esther Arnaiz et al.
Frontiers in oncology, 11, 779739-779739 (2021-12-14)
Hypoxia is a common phenomenon in solid tumours strongly linked to the hallmarks of cancer. Hypoxia promotes local immunosuppression and downregulates type I interferon (IFN) expression and signalling, which contribute to the success of many cancer therapies. Double-stranded RNA (dsRNA)
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