I4657
Insulin-like Growth Factor-I Receptor human
≥95% (SDS-PAGE), recombinant, expressed in NSO cells, lyophilized powder
别名:
IGF-I Receptor
生物来源
human
质量水平
重组
expressed in NSO cells
方案
≥95% (SDS-PAGE)
表单
lyophilized powder
分子量
α-chain ~120 & 150 kDa
β subunit ~46 & 50 kDa
包装
pkg of 50 μg
杂质
endotoxin, tested
UniProt登记号
储存温度
−20°C
基因信息
human ... IGF1R(3480)
相关类别
一般描述
IGF1R (insulin-like growth factor I) is a receptor tyrosine kinase. The gene is mapped to human chromosome 15q26. It is expressed in various solid tumors as well as hematologic malignancies.
应用
Insulin-like growth factor-I receptor human has been used to study the binding constants of estradiol to insulin, insulin receptors and insulin-like peptides.
生化/生理作用
Binds IGF-I with high affinity, IGF-II with lower affinity, and insulin with weak affinity.
IGF-I receptor, a tyrosine kinase receptor with signal transduction pathways, is comprised of two α and two β subunits. IGF-I receptor binds IGF-I with high affinity, IGF-II with lower affinity, and insulin with weak affinity.
外形
Lyophilized from a 0.2 μm solution in phosphate buffered saline.
分析说明
As a result of glycosylation in SDS-PAGE under reducing conditions, the recombinant α subunit migrates as a doublet of ~120 kDa and 150 kDa and the β subunit migrates as doublet of ~46 kDa and 50 kDa.
The biological activity is measured by its ability to bind human IGF-I in a functional ELISA assay.
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
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