一般描述
IgG 有 4 种同种型 IgG1、IgG2、IgG3 和 IgG4。它包含 4 个多肽链，由 2 条相同的 50 kDa γ 重（H）链和 2 条相同的 25 kDa κ或 λ 轻（L）链组成，它们通过链间二硫键连接。
应用
纯化的 IgG 可用作各种免疫测定中的参考抗原、标准品、封闭剂或包被蛋白，包括 ELISA、斑点免疫结合、蛋白免疫印迹、免疫扩散、免疫沉淀和免疫电泳等。其他应用包括作为制备免疫原和固相免疫吸附剂的起始材料。
生化/生理作用
IgG 介导经胎盘转运并参与二次免疫反应。IgG 激活补体系统的经典途径。它中和病毒颗粒和毒素。IgG 在抗体依赖性细胞介导的细胞毒性（ADCC）和吞噬作用中起关键作用。它可能与过敏有关。它具有最长的血清半衰期。
IgG抗体亚型是免疫系统中最丰富的血清免疫球蛋白。它由B细胞分泌，存在于血液和细胞外液中，可防止细菌、真菌和病毒引起的感染。母体IgG可通过胎盘转移至胎儿，胎盘对新生儿免疫防御感染至关重要。
分析说明
蛋白质浓度应在重组后通过 280 nm 处的吸光度（E1%/280 = 14）测定。
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储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
法规信息
低风险生物材料
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Agnieszka Gambus et al.
Cell cycle (Georgetown, Tex.), 12(8), 1225-1232 (2013-03-23)
Hexameric complexes of the six related Mcm2-7 proteins form the core of the replicative helicase. Two other proteins, Mcm8 and Mcm9, with significant homology to Mcm2-7 were first shown to play distinct roles during DNA replication in Xenopus laevis egg
Deepmala Karmakar et al.
Carcinogenesis, 41(12), 1767-1780 (2020-05-10)
Previously, our laboratory demonstrated that a deregulated E2F5/p38/SMAD3 axis was associated with uncontrolled cellular proliferation in prostate cancer (PCa). Here, we investigate the role of E2F5 in PCa in further details. RNAi-mediated E2F5 knockdown and pathway-focused gene expression profiling in
Bijurica Chakraborty et al.
EBioMedicine, 37, 442-452 (2018-10-20)
Plasmodium falciparum and Plasmodium vivax are two major parasites responsible for malaria which remains a threat to almost 50% of world's population despite decade-long eradication program. One possible reason behind this conundrum is that the bases of clinical variability in
Kai Kessenbrock et al.
The Journal of clinical investigation, 118(7), 2438-2447 (2008-06-24)
Neutrophil granulocytes form the body's first line of antibacterial defense, but they also contribute to tissue injury and noninfectious, chronic inflammation. Proteinase 3 (PR3) and neutrophil elastase (NE) are 2 abundant neutrophil serine proteases implicated in antimicrobial defense with overlapping
Anil K Pal et al.
Biosensors, 10(10) (2020-09-30)
We report a novel self-referenced diffraction-based leaky waveguide (LW) comprising a thin (~2 µm) film of a photofunctionalisable hydrogel created by covalent attachment of a biotinylated photocleavable linker to chitosan. Streptavidin attached to the chitosan via the photocleavable linker was
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