I5659
艾地苯醌
≥98% (HPLC), powder
别名:
2-(10-hydroxydecyl)-5,6-dimethoxy-3-methylcyclohexa-2,5-diene-1,4-dione
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关于此项目
经验公式（希尔记法）:
C19H30O5
化学文摘社编号:
分子量:
338.44
MDL编号:
UNSPSC代码:
12352204
PubChem化学物质编号:
NACRES:
NA.25
产品名称
艾地苯醌, ≥98% (HPLC)
方案
≥98% (HPLC)
表单
powder
溶解性
methanol: 50 mg/mL, clear to slightly hazy
储存温度
room temp
SMILES字符串
O=C(C(OC)=C1OC)C(CCCCCCCCCCO)=C(C)C1=O
InChI
1S/C19H30O5/c1-14-15(12-10-8-6-4-5-7-9-11-13-20)17(22)19(24-3)18(23-2)16(14)21/h20H,4-13H2,1-3H3
InChI key
JGPMMRGNQUBGND-UHFFFAOYSA-N
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一般描述
艾地苯醌是一种短链苯醌类药物。
应用
艾地苯醌已用于:
- 处理用于药物治疗测定的突变肌纤蛋白 (mMYOC)细胞
- 验证 C2C12 二次细胞筛选测定
- 处理肥胖小鼠，测试艾地苯醌和 CoQ10 是否直接结合过氧化物酶体增殖物激活受体(PPAR）LBD、His 标记的 PPAR αδ 和γ LBD。
生化/生理作用
一种短链辅酶 Q 类似物，可通过介导电子从 N2 转移到氧来增强超氧化物的形成。
艾地苯醌用于治疗患有 Leber′遗传性视神经病变 （LHON）的青少年和成人的视力障碍。它可用作抗氧化剂。它有助于保护心肌免于氧化应激。
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Ruth Goldschmidt et al.
Bioorganic & medicinal chemistry, 21(4), 969-978 (2013-01-15)
Two new aza analogues of the neuroprotective agent idebenone have been synthesized and characterized. Their antioxidant activity, and ability to augment ATP levels have been evaluated in several different cell lines having suboptimal mitochondrial function. Both compounds were found to
Idebenone and reduced cardiac hypertrophy in Friedreich's ataxia
Hausse AO, et al.
Heart, 87(4), 346-349 (2002)
Persistence of the treatment effect of idebenone in Leber's hereditary optic neuropathy.
T Klopstock et al.
Brain : a journal of neurology, 136(Pt 2), e230-e230 (2013-02-08)
Carolyn P Ojano-Dirain et al.
The Laryngoscope, 122(11), 2543-2548 (2012-09-12)
Antioxidants have been shown to protect against aminoglycoside-induced hearing loss. Mitoquinone (MitoQ) is a mitochondria-targeted derivative of the antioxidant ubiquinone. MitoQ is attached to a lipophilic triphenylphosphonium (TPP) cation, which enables its accumulation inside the mitochondria several hundred-fold over the
Oliver Gamondi et al.
Drug metabolism letters, 6(2), 120-123 (2012-09-15)
We investigated the damage caused by oxidative stress using the yeast Saccharomyces cerevisiae as a model biological system. After inducing oxidative stress with menadione, we were able to evaluate the extent of cellular oxidative stress by utilizing 2',7'-dichlorofluorescein diacetate (DCFH-DA)
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