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I6383

氧化胰岛素链 B 来源于牛胰腺

Name: 氧化胰岛素链 B 来源于牛胰腺
Brand: SIGMA

≥80% (HPLC), powder

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关于此项目

经验公式（希尔记法）:

C₁₅₇H₂₃₂N₄₀O₄₇S₂

化学文摘社编号:

30003-72-6

分子量:

3495.89

UNSPSC Code:

12352202

NACRES:

NA.77

MDL number:

MFCD00131380

Biological source:

bovine

Form:

powder

Assay:

≥80% (HPLC)

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biological source

bovine

Quality Level

200

sterility

non-sterile

assay

≥80% (HPLC)

form

powder

mol wt

3496 Da by calculation (Average Mass)

UniProt accession no.

P01317

shipped in

ambient

storage temp.

−20°C

SMILES string

[S](=O)(=O)(O)C[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](N)Cc8c

InChI

1S/C157H232N40O47S2/c1-79(2)57-104(181-130(211)86(15)172-136(217)103(50-53-125(209)210)180-152(233)127(84(11)12)194-148(229)107(60-82(7)8)184-145(226)113(67-95-70-165-78-171-95)189-150(231)115(74-198)176-123(206)73-169-133(214)116(75-245(239,240)241)191-140(221)105(58-80(3)4)182-144(225)112(66-94-69-164-77-170-94)188-138(219)102(48-51-119(160)202)178-146(227)114(68-120(161)203)190-153(234)126(83(9)10)193-131(212)98(159)61-89-31-21-18-22-32-89)139(220)185-110(64-92-40-44-96(200)45-41-92)142(223)183-106(59-81(5)6)147(228)195-128(85(13)14)154(235)192-117(76-246(242,243)244)134(215)168-71-121(204)174-101(49-52-124(207)208)137(218)177-99(38-29-55-166-157(162)163)132(213)167-72-122(205)175-108(62-90-33-23-19-24-34-90)141(222)186-109(63-91-35-25-20-26-36-91)143(224)187-111(65-93-42-46-97(201)47-43-93)149(230)196-129(88(17)199)155(236)197-56-30-39-118(197)151(232)179-100(37-27-28-54-158)135(216)173-87(16)156(237)238/h18-26,31-36,40-47,69-70,77-88,98-118,126-129,198-201H,27-30,37-39,48-68,71-76,158-159H2,1-17H3,(H2,160,202)(H2,161,203)(H,164,170)(H,165,171)(H,167,213)(H,168,215)(H,169,214)(H,172,217)(H,173,216)(H,174,204)(H,175,205)(H,176,206)(H,177,218)(H,178,227)(H,179,232)(H,180,233)(H,181,211)(H,182,225)(H,183,223)(H,184,226)(H,185,220)(H,186,222)(H,187,224)(H,188,219)(H,189,231)(H,190,234)(H,191,221)(H,192,235)(H,193,212)(H,194,229)(H,195,228)(H,196,230)(H,207,208)(H,209,210)(H,237,238)(H4,162,163,166)(H,239,240,241)(H,242,243,244)/t86-,87-,88+,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,113-,114-,115-,116-,117-,118-,126-,127-,128-,129-/m0/s1

InChI key

CZJQESISDHGFTC-DQCCOYHDSA-N

Gene Information

cow ... INS(280829)

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General description

Insulin is made up of two polypeptide chains (A and B) linked together by two disulfide linkages. Chain A and B are composed of 21 amino acids and 30 amino acids, respectively.

Application

Insulin Chain B Oxidized from bovine pancreas has been used:

as a matrix-assisted laser desorption/ionization (MALDI)-mass spectrometry (MS) calibration standard
in electrochemical impedance spectroscopy and quartz crystal nanobalance (EQCN) studies of insulin adsorption on platinum
as an internal standard to quantify insulin chain B residue in protein samples

Biochem/physiol Actions

胰岛素调节细胞对葡萄糖、氨基酸和脂肪酸的摄取、使用和储存。可抑制糖原、蛋白质和脂肪的降解。β 链是羧肽酶 Y 的底物。

Preparation Note

制备参照 Sanger, F. 等人的方法并加以改进

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

法规信息

低风险生物材料

常规特殊物品

兴奋剂肽类激素

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Electrochemical impedance spectroscopy and quartz crystal nanobalance (EQCN) studies of insulin adsorption on Pt

Wright JEI, et al.

Journal of Electroanalytical Chemistry, 564, 185-197 (2004)

Johansen, J.T., et al.

Carlsberg Research Communications, 41, 1-1 (1976)

Epitope mapping by a combination of epitope excision and MALDI-MS.

C E Parker et al.

Methods in molecular biology (Clifton, N.J.), 146, 185-201 (2000-08-19)

337 nm matrix-assisted laser desorption/ionization of single aerosol particles.

L He et al.

Journal of mass spectrometry : JMS, 34(9), 909-914 (1999-09-24)

Matrix-assisted laser desorption/ionization (MALDI) mass spectra were obtained from single particles injected directly into a time-of-flight mass spectrometer. Aerosol particles were generated at atmospheric pressure using a piezoelectric single-particle generator or a pneumatic nebulizer and introduced into the mass spectrometer

MALDI/MS-based epitope mapping of antigens bound to immobilized antibodies.

Carol E Parker et al.

Molecular biotechnology, 20(1), 49-62 (2002-03-06)

Proteolytic digestion of proteins bound to immobilized antibodies, combined with matrix assisted laser desorption (MALDI) mass spectrometric identification of the affinity-bound peptides, can be a powerful technique for epitope determination. Binding of the protein to the antibody is done while

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全球贸易项目编号

货号	GTIN
I6383-10MG	04061832820712
I6383-5MG	04061832820736
I6383-1MG	04061826284865
I6383-50MG	04061832820729

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