Application
吲哚-3-甲醇用于封装聚-乳酸-co-乙醇酸 (PLGA)，以研究其对乳腺腺癌上皮细胞(MCF7)、结肠腺癌上皮细胞(Caco2)、前列腺癌上皮细胞(PC3)的体外抗癌效果。它还被用作细胞色素P4501A (CYP1A)诱导物。
Biochem/physiol Actions
吲哚-3-甲醇(I3C)激活芳烃受体(AhR)，诱导G1细胞周期阻滞和凋亡。因此，它是一种潜在的抗癌剂。此外，它通过刺激细胞色素P450酶来诱导雌二醇代谢。因此，I3C被认为是一种有效的化疗药物，用于各种类型的癌症，包括乳腺癌、前列腺癌、结肠癌和白血病。
在起始阶段抑制致癌症发生。已经证明在几种动物中具有抑制癌症发生的作用，但如果在发病后阶段给药，它会增加肿瘤的发病率。 在十字花科蔬菜中发现。
General description
吲哚-3-甲醇是十字花科蔬菜中产生的一种新的次生植物代谢产物，例如卷心菜、花椰菜和抱子甘蓝等。
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Warning
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Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2
存储类别
11 - Combustible Solids
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WGK 3
ppe
dust mask type N95 (US), Eyeshields, Gloves
Profiling the hepatic effects of flutamide in rats: a microarray comparison with classical aryl hydrocarbon receptor ligands and atypical CYP1A inducers
Coe KJ, et al.
Drug Metabolism and Disposition, 34(7), 1266-1275 (2006)
PLGA encapsulation and radioiodination of indole-3-carbinol: investigation of anticancerogenic effects against MCF7, Caco2 and PC3 cells by in vitro assays
Yildiz G, et al.
J. Radioanal. Nucl. Chem., 311(2), 1043-1052 (2017)
Jing-Ru Weng et al.
Cancer letters, 262(2), 153-163 (2008-03-04)
During the course of oncogenesis and tumor progression, cancer cells constitutively upregulate signaling pathways relevant to cell proliferation and survival as a strategy to overcome genomic instability and acquire resistance phenotype to chemotherapeutic agents. In light of this clinical and
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Parkinson's disease (PD) is a progressive neurodegenerative disorder, majorly with symptoms of motor dysfunction. Study was performed to explore the effect of nuclear factor κB (NF-κB) inhibitors against neurobehavioral abnormalities and neuroinflammation in PD. Cost effective in silico approaches of
G S Bailey et al.
Journal of the National Cancer Institute, 78(5), 931-934 (1987-05-01)
Indole-3-carbinol (I3C), a natural constituent of cruciferous vegetables, is an inhibitor in several experimental animal models of carcinogenesis by polynuclear aromatic hydrocarbons or aflatoxin B1 (AFB1) when administered prior to or during carcinogen exposure. For assessment of the postinitiation effects
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