Merck
CN

I7378

Sigma-Aldrich

吲哚美辛

98.5-100.5% (in accordance with EP)

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别名:
1-(4-氯苯甲酰基)-5-甲氧基-2-甲基-3-吲哚乙酸
Empirical Formula (Hill Notation):
C19H16ClNO4
CAS号:
分子量:
357.79
Beilstein:
497341
EC 号:
MDL编号:
PubChem化学物质编号:
NACRES:
NA.77

生物来源

synthetic

质量水平

检测方案

98.5-100.5% (in accordance with EP)

形式

powder or crystals

缺失

≤0.5% loss on drying

mp

158-162 °C

作用机制

enzyme | inhibits

SMILES string

COc1ccc2n(c(C)c(CC(O)=O)c2c1)C(=O)c3ccc(Cl)cc3

InChI

1S/C19H16ClNO4/c1-11-15(10-18(22)23)16-9-14(25-2)7-8-17(16)21(11)19(24)12-3-5-13(20)6-4-12/h3-9H,10H2,1-2H3,(H,22,23)

InChI key

CGIGDMFJXJATDK-UHFFFAOYSA-N

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此商品
I8280PHR1247405268
Indomethacin 98.5-100.5% (in accordance with EP)

Sigma-Aldrich

I7378

吲哚美辛

Indomethacin meets USP testing specifications

Sigma-Aldrich

I8280

吲哚美辛

Indomethacin Pharmaceutical Secondary Standard; Certified Reference Material

Supelco

PHR1247

吲哚美辛

Indomethacin A non-steroidal anti-inflammatory, cell permeable, antipyretic agent.

Sigma-Aldrich

405268

Indomethacin

form

powder or crystals

form

powder

form

-

form

powder

Quality Level

200

Quality Level

-

Quality Level

300

Quality Level

100

biological source

synthetic

biological source

-

biological source

-

biological source

-

loss

≤0.5% loss on drying

loss

-

loss

-

loss

-

mp

158-162 °C

mp

-

mp

-

mp

-

一般描述

吲哚美辛是环加氧酶1和2的抑制剂。吲哚美辛可对胃肠道、肾脏和大脑产生副作用。吲哚美辛与布洛芬一起使用,可有效治疗患有呼吸窘迫综合征的婴儿的动脉导管未闭(PDA)。吲哚美辛直肠给药可有效治疗内镜下逆行胰胆管造影(ERCP)诱发的胰腺炎。

应用

吲哚美辛已被用于:
  • 在人骨髓干细胞的成骨和脂肪形成分化测定中作为培养基补充剂
  • 作为牛羊水干细胞(BAFSCs)培养的培养基补充剂
  • 抑制T细胞的前列腺素E2(PGE2)生成

生化/生理作用

环加氧酶 (COX) 抑制剂,对 COX-1 的选择性相对较高。

特点和优势

《受体分类和信号转导》手册的 前列腺素类受体 页面有该化合物的介绍。想要浏览手册的其他页面, 请单击此处
该化合物是ADME Tox研究的特色产品。点击此处 ,查看更多ADME Tox精选产品。想要了解有关生物活性小分子在其他研究领域应用的更多信息,请访问 sigma.com/discover-bsm

象形图

Skull and crossbones

警示用语:

Danger

危险声明

危险分类

Acute Tox. 1 Oral

储存分类代码

6.1A - Combustible, acute toxic Cat. 1 and 2 / very toxic hazardous materials

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges


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