I8021
L-N6-（1-亚氨乙基）赖氨酸 二盐酸盐
别名:
L-NIL 二盐酸盐, L-赖氨酸ω-乙脒 二盐酸盐
登录 查看组织和合同定价。
选择尺寸
变更视图
关于此项目
经验公式（希尔记法）:
C8H17N3O2 · 2 HCl
化学文摘社编号:
分子量:
260.16
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352209
MDL number:
Assay:
≥97% (HPLC)
Form:
powder
biological source
synthetic (organic)
assay
≥97% (HPLC)
form
powder
solubility
water: 50 mg/mL, clear, colorless
storage temp.
−20°C
SMILES string
Cl.Cl.CC(=N)NCCCC[C@H](N)C(O)=O
InChI
1S/C8H17N3O2.2ClH/c1-6(9)11-5-3-2-4-7(10)8(12)13;;/h7H,2-5,10H2,1H3,(H2,9,11)(H,12,13);2*1H/t7-;;/m0../s1
InChI key
OQIBCXRAFAHXMM-KLXURFKVSA-N
Gene Information
human ... NOS2(4843)
Application
L-N6-（1-亚氨乙基）赖氨酸二盐酸盐已被用作诱导型一氧化氮合酶（iNOS）抑制剂：
- 研究其对瘦素诱导的小鼠心肌细胞和脂肪细胞中纤维连接蛋白Ⅲ型域包含蛋白五（FNDC5）/鸢尾素的调节作用
- 研究其对瘦素诱导的肝细胞炎症的影响
- 阻断小鼠骨髓间充质基质细胞（BMSCs）中一氧化氮的生成
Biochem/physiol Actions
诱导型一氧化氮合酶（iNOS）的选择性抑制剂。
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
Sara Becerril et al.
Genes, 10(3) (2019-03-02)
iNOS deficiency in ob/ob mice improved liver inflammation and ECM remodeling-related genes, decreasing fibrosis, and metabolic dysfunction. The activation of iNOS by leptin is necessary for the synthesis and secretion of TNC in hepatocytes, suggesting an important role of this
W M Moore et al.
Journal of medicinal chemistry, 37(23), 3886-3888 (1994-11-11)
L-N6-(1-Iminoethyl)lysine (L-NIL) has been synthesized and is shown to be both a potent and selective inhibitor of mouse inducible nitric oxide synthase (miNOS). L-NIL has an IC50 of 3.3 microM for miNOS compared to an IC50 of 92 microM for
Nikolai V Gorbunov et al.
Journal of cellular and molecular medicine, 19(5), 1133-1150 (2015-02-28)
The bone marrow stroma constitutes the marrow-blood barrier, which sustains immunochemical homoeostasis and protection of the haematopoietic tissue in sequelae of systemic bacterial infections. Under these conditions, the bone marrow stromal cells affected by circulating bacterial pathogens shall elicit the
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| I8021-10MG | 04061833262719 |