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Merck
CN

I8280

吲哚美辛

meets USP testing specifications

别名:

1-(4-氯苯甲酰基)-5-甲氧基-2-甲基-3-吲哚乙酸

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关于此项目

经验公式（希尔记法）:
C19H16ClNO4
化学文摘社编号:
53-86-1
分子量:
357.79
UNSPSC Code:
12352101
NACRES:
NA.21
PubChem Substance ID:
24896136
EC Number:
200-186-5
Beilstein/REAXYS Number:
497341
MDL number:
MFCD00057095

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产品名称

吲哚美辛, meets USP testing specifications

InChI key

CGIGDMFJXJATDK-UHFFFAOYSA-N

InChI

1S/C19H16ClNO4/c1-11-15(10-18(22)23)16-9-14(25-2)7-8-17(16)21(11)19(24)12-3-5-13(20)6-4-12/h3-9H,10H2,1-2H3,(H,22,23)

SMILES string

COc1ccc2n(c(C)c(CC(O)=O)c2c1)C(=O)c3ccc(Cl)cc3

agency

USP/NF
meets USP testing specifications

assay

98.0-102.0%

form

powder

mode of action

enzyme | inhibits

Quality Level

200

Gene Information

human ... ALB(213), ALOX5(240), ELA2(1991), GPR44(11251), IL1A(3552), PLA2G1B(5319), PTGDR(5729), PTGS1(5742), PTGS2(5743)
mouse ... Alox5(11689), Ptgdr(19214), Ptger1(19216), Ptger2(19217), Ptger3(19218), Ptger4(19219), Ptgs1(19224), Ptgs2(19225)
rat ... Alox5(25290), Ptgs1(24693), Ptgs2(29527)

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相关类别

Biochem/physiol Actions

环加氧酶 (COX) 抑制剂，对 COX-1 的选择性相对较高。
用作环氧合酶的非选择性抑制剂 COX1 和 COX2，导致从花生四烯酸合成前列腺素减少。

pictograms

Skull and crossbones
GHS06

signalword

Danger

hcodes

H300

Hazard Classifications

Acute Tox. 1 Oral

存储类别

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
WXBF3900V
WXBD8285V
MKCK2005
MKCD0036
MKBR4530V

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Amal M Youssef et al.
Bioorganic & medicinal chemistry, 18(5), 2019-2028 (2010-02-09)
Novel pyrazolyl-2,4-thiazolidinediones were prepared via the reaction of appropriate pyrazolecarboxaldehydes with 2,4-thiazolidinediones and substituted benzyl-2,4-thiazolidinediones. The resultant compounds were first evaluated for their anti-inflammatory and neuroprotective properties in vitro. The active compounds were further studied in vivo by using the
Dongfei Liu et al.
Journal of controlled release : official journal of the Controlled Release Society, 170(2), 268-278 (2013-06-13)
Nanoparticulate drug delivery systems offer remarkable opportunities for clinical treatment. However, there are several challenges when they are employed to deliver multiple cargos/payloads, particularly concerning the synchronous delivery of small molecular weight drugs and relatively larger peptides. Since porous silicon
Christel A S Bergström et al.
Journal of medicinal chemistry, 50(23), 5858-5862 (2007-10-13)
We determined the intrinsic aqueous solubility of 15 poorly soluble drugs with solubilities ranging from 2.9 nM to 1.1 microM. We then analyzed the data from a physicochemical perspective, using experimentally determined solid-state properties and easily interpretable two-dimensional molecular descriptors
Marsel Lino et al.
Molecular metabolism, 39, 101006-101006 (2020-05-04)
Discoidin domain receptor 1 (DDR1) is a collagen binding receptor tyrosine kinase implicated in atherosclerosis, fibrosis, and cancer. Our previous research showed that DDR1 could regulate smooth muscle cell trans-differentiation, fibrosis and calcification in the vascular system in cardiometabolic disease.
Zhangjian Huang et al.
Journal of medicinal chemistry, 54(5), 1356-1364 (2011-02-02)
The carboxylic acid group of the anti-inflammatory (AI) drugs indo-methacin, (S)-naproxen and ibuprofen was covalently linked via a two-carbon ethyl spacer to a sulfohydroxamic acid moiety (CH(2)CH(2)SO(2)NHOH) to furnish a group of hybrid ester prodrugs that release nitric oxide (NO)
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