生物来源
human
质量水平
重组
expressed in NSO cells
方案
>90% (SDS-PAGE)
表单
lyophilized powder
效能
0.5-1.5 mg per mL ED50
分子量
34 kDa by SDS-PAGE (reducing)
calculated mol wt ~28 kDa
包装
pkg of 25 μg
杂质
endotoxin, tested
UniProt登记号
储存温度
−20°C
基因信息
human ... IGFBP5(3488)
一般描述
The gene IGFBP-5 (insulin-like growth factor binding protein-5) is mapped to human chromosome 2q35.
生化/生理作用
Binds to bone cells and is the predominant insulin-like growth factor binding protein in bone; when binding the extracellular matrix, it modulates IGF activity.
IGFBP-5 (insulin-like growth factor binding protein-5) interacts with IGFs and thereby controls IGF activity. High levels of IGFBP5 are present in systemic sclerosis and idiopathic pulmonary fibrosis conditions. It also plays a crucial role in cancer progression.
IGFBP-5 binds to bone cells and is the predominant insulin-like growth factor binding protein in bone. When IGFBP-5 binds the extracellular matrix, it modulates IGF activity. Mouse, human, and rat IGFBP-5 share 97% homology.
外形
Lyophilized from a 0.2 μm filtered solution in 30% acetonitrile and 0.1% TFA.
分析说明
The biological activity is measured by its ability to inhibit recombinant human IGF-1 or IGF-II on MCF-7 cells.
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
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