I8757
4-碘- L -苯丙氨酸
≥98.0% (TLC)
别名:
( S )-2-氨基-3-（4-碘苯基）丙酸
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关于此项目
经验公式（希尔记法）:
C9H10INO2
化学文摘社编号:
分子量:
291.09
Beilstein:
4411317
MDL编号:
UNSPSC代码:
12352209
PubChem化学物质编号:
NACRES:
NA.26
产品名称
4-碘- L -苯丙氨酸,
方案
≥98.0% (TLC)
表单
powder
颜色
white to off-white
储存温度
−20°C
SMILES字符串
N[C@@H](Cc1ccc(I)cc1)C(O)=O
InChI
1S/C9H10INO2/c10-7-3-1-6(2-4-7)5-8(11)9(12)13/h1-4,8H,5,11H2,(H,12,13)/t8-/m0/s1
InChI key
PZNQZSRPDOEBMS-QMMMGPOBSA-N
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生化/生理作用
4-碘-L-苯丙氨酸可作为模型非天然 α通过蛋白石 (UGA) 密码子改变主要氨基酸组成的氨基酸。
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
S Samnick et al.
European journal of nuclear medicine, 27(10), 1543-1551 (2000-11-18)
In developing iodine-123-labelled amino acid derivatives for imaging cerebral gliomas by single-photon emission tomography (SPET), we compared p-[123I]iodo-L-phenylalanine (IPA), L-[123I]iodo-1,2,3,4-tetrahydro-7-hydroxyisoquinoline-3-carboxylic acid (ITIC) and L-3-[123I]iodo-alpha-methyltyrosine (IMT) with regard to their uptake in human glioblastoma T99 and T3868 cells, and thereafter studied
Dirk Hellwig et al.
European journal of nuclear medicine and molecular imaging, 32(9), 1041-1049 (2005-05-20)
The aims of this prospective study were to validate single-photon emission computed tomography (SPECT) with p-[(123)I]iodo-L-phenylalanine (IPA) in brain tumours and to evaluate its potential for the characterisation of indeterminate brain lesions. In 45 patients with indeterminate brain lesions or
D R Harding et al.
International journal of peptide and protein research, 26(2), 208-213 (1985-08-01)
The amino terminal fragment (1-15) of apolipoprotein C-1, H-Thr-Pro-Asp-Val-Ser-Ser-Ala-Leu-Asp-Lys-Leu-Lys-Glu-Phe14-Gly was prepared by the solid phase method. However, the phenylalanine residue at position 14 was replaced with p-iodophenylalanine in the chemical synthesis. The preparation of t-butyloxy-carbonyl-p-iodophenylalanine is described. After completion of
Samuel Samnick et al.
European journal of nuclear medicine and molecular imaging, 31(4), 532-541 (2004-01-15)
Pancreatic cancer is associated with the worst 5-year survival rate of any human cancer. This high mortality is due, in part, to difficulties in establishing early and accurate diagnosis. Because most tumours share the ability to accumulate amino acids more
D Hellwig et al.
Nuklearmedizin. Nuclear medicine, 47(5), 220-224 (2008-10-15)
Recently, p-[(123)I]iodo-L-phenylalanine (IPA) was clinically validated for brain tumour imaging. Preclinical studies demonstrated uptake of IPA into pancreatic adenocarcinoma suggesting its diagnostic application in patients with pancreatic tumours. The aim was to study the tumour uptake of IPA in patients
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