伊维菌素

Name: 伊维菌素
Brand: SIGMA

别名:

22,23-二氢阿维菌素 B1, MK-933

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所有图片(3)

About This Item

CAS Number:

70288-86-7

MDL编号:

MFCD00869511

UNSPSC代码:

12352200

PubChem化学物质编号:

24278497

NACRES:

NA.77

表单

powder

质量水平

100

溶解性

MEK: 50 mg/mL

抗生素抗菌谱

parasites

应用

agriculture
environmental

作用机制

cell membrane | interferes

创始人

Merck & Co., Inc., Kenilworth, NJ, U.S.

储存温度

2-8°C

SMILES字符串

[H][C@@]1(O[C@]2(CC[C@@H]1C)C[C@@H]3C[C@@H](C\C=C(C)\[C@@H](O[C@H]4C[C@H](OC)[C@@H](O[C@H]5C[C@H](OC)[C@@H](O)[C@H](C)O5)[C@H](C)O4)[C@@H](C)\C=C\C=C6/CO[C@]7([H])[C@H](O)C(C)=C[C@@H](C(=O)O3)[C@]67O)O2)[C@@H](C)CC

InChI

1S/C48H74O14/c1-11-25(2)43-28(5)17-18-47(62-43)23-34-20-33(61-47)16-15-27(4)42(26(3)13-12-14-32-24-55-45-40(49)29(6)19-35(46(51)58-34)48(32,45)52)59-39-22-37(54-10)44(31(8)57-39)60-38-21-36(53-9)41(50)30(7)56-38/h12-15,19,25-26,28,30-31,33-45,49-50,52H,11,16-18,20-24H2,1-10H3/b13-12+,27-15+,32-14+/t25-,26-,28-,30-,31-,33+,34-,35-,36-,37-,38-,39-,40+,41-,42-,43+,44-,45+,47+,48+/m0/s1

InChI key

AZSNMRSAGSSBNP-XPNPUAGNSA-N

基因信息

human ... ABCB1(5243), CYP3A4(1576)
mouse ... Abcb1a(18671), Abcb1b(18669)

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一般描述

Ivermectin is a macro-cyclic lactone, derived from avermectin. It functions as an antiparasitic agent. Ivermectin is used against gastrointestinal roundworms, lungworms, mites and lice. It is used to treat onchocerciasis, strongyloidiasis, ascariasis and filariases.

应用

Ivermectin has been used:

in Caenorhabditis elegans fecundity assay
in larval development test
to measure in vivo topical acaricide activity of compounds in rats
to assess its acute and chronic effects to zebrafish
in percutaneous drug injection method to treat cystic echinococcosis
in liquid chromatography with fluorescence detection method

生化/生理作用

Positive allosteric modulator of α7 neuronal nicotinic acetylcholine receptor; also modulates glutamate-GABA-activated chloride channels.

特点和优势

This compound is featured on the Acetylcholine Receptors (Nicotinic) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Merck & Co., Inc., Kenilworth, NJ, U.S.. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.