生物来源
rat
质量水平
重组
expressed in CHO cells
方案
≥95%
表单
lyophilized powder
分子量
~20 kDa
包装
pkg of 1 vial
浓度
≥100000 units/mL
技术
cell culture | mammalian: suitable
UniProt登记号
运输
dry ice
储存温度
−70°C
基因信息
rat ... Ifnb1(24481)
生化/生理作用
Cytokine with anti-viral, anti-proliferative, immunoregulatory, and proinflammatory activities.
Interferon β belongs to the type 1 interferon family pf proteins. It is also needed for the inhibition of tumor cell growth via cell death, S-phase increase and mediating differentiation. It is also important for bone homeostasis.
外形
Lyophilized from phosphate buffered saline (PBS) containing 125 mM trehalose.
分析说明
The biological activity is determined in the cytopathic effect inhibition assay using rat epithelial-like (RATEC) cells with vesicular stomatitis virus (VSV). The cytopathic effect of 50% is produced with approximately 1 unit/ml interferon. Since there is no international rat interferon β standard, units are determined with respect to the NIH international standard reference for mouse interferon α/β.
储存分类代码
13 - Non Combustible Solids
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
法规信息
新产品
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
R B Pepinsky et al.
The Journal of pharmacology and experimental therapeutics, 297(3), 1059-1066 (2001-05-18)
Interferon therapies suffer from a relatively short half-life of the products in circulation. To address this issue we investigated the effects of polyethylene glycol modification (PEGylation) on the pharmacokinetic properties of human interferon (IFN)-beta-1a. PEGylation with a linear 20-kDa PEG
C Ren et al.
Gene therapy, 15(21), 1446-1453 (2008-07-04)
Cell-based therapy for cancer is a promising new field. Among cell types that can be used for this purpose, mesenchymal stem cells (MSCs) appear to hold great advantage for reasons including easier propagation in culture, possible genetic modification to express
J Adriaansen et al.
Human gene therapy, 17(10), 985-996 (2006-09-21)
Interferon (IFN)-beta has significant immunomodulatory properties and has received much interest as a potentially therapeutic agent for rheumatoid arthritis (RA). Systemic IFN-beta treatment of patients with RA was not effective, probably because of pharmacokinetic issues. Therefore, we studied the effect
Junqiang Ye et al.
PloS one, 6(6), e20681-e20681 (2011-06-17)
The production of type I interferons (IFNs) in response to viral infections is critical for antiviral immunity. However, IFN production is transient, and continued expression can lead to inflammatory or autoimmune diseases. Thus, understanding the mechanisms underlying the negative regulation
Interferon standards and general abbreviations.
S Pestka
Methods in enzymology, 119, 14-23 (1986-01-01)
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