质量水平
方案
≥90%
储存温度
−20°C
SMILES字符串
[Li+].[Li+].[Li+].[H]O[H].CC(C)CC(=O)SCCNC(=O)CCNC(=O)[C@H](O)C(C)(C)COP([O-])(=O)OP([O-])(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1OP(O)([O-])=O)n2cnc3c(N)ncnc23
InChI
1S/C26H44N7O17P3S.3Li.H2O/c1-14(2)9-17(35)54-8-7-28-16(34)5-6-29-24(38)21(37)26(3,4)11-47-53(44,45)50-52(42,43)46-10-15-20(49-51(39,40)41)19(36)25(48-15)33-13-32-18-22(27)30-12-31-23(18)33;;;;/h12-15,19-21,25,36-37H,5-11H2,1-4H3,(H,28,34)(H,29,38)(H,42,43)(H,44,45)(H2,27,30,31)(H2,39,40,41);;;;1H2/q;3*+1;/p-3/t15-,19-,20-,21+,25-;;;;/m1..../s1
InChI key
RABPIYFVNICBEC-YVBWDKSKSA-K
一般描述
异戊酰辅酶 A 是亮氨酸分解代谢的中间产物。Iv-CoA由β甲基丁酸在酯酰辅酶A合成酶的催化下而合成。在亮氨酸分解代谢途径中，异戊酰辅酶A脱氢酶将异戊酰辅酶A转化为甲基巴豆酰辅酶A。异戊酰辅酶A氧化酶同样也催化脂肪酸β-氧化途径中的这一转化。
应用
异戊酰辅酶A (IV-CoA) 锂盐水合物可用于：
- 作为G. reessii无细胞抽提物中β-羟基-β-甲基丁酸的合成底物
- 在高效液相色谱 (HPLC) 中用于表征淋巴细胞中的IV-CoA
- 在异戊酰辅酶A脱氢酶分析中作为底物
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
Lee et al.
Archives of microbiology, 169(3), 257-262 (1998-03-28)
Galactomyces reessii accomplishes the enzymatic transformation of beta-methylbutyric acid (isovaleric acid) to beta-hydroxy-beta-methylbutyric acid. The enzymatic basis for this bioconversion was evaluated by analyzing cell-free extracts of G. reessii for enzyme activities commonly associated with leucine catabolism. G. reessii extracts
K Däschner et al.
Plant physiology, 126(2), 601-612 (2001-06-13)
We recently identified a cDNA encoding a putative isovaleryl-coenzyme A (CoA) dehydrogenase in Arabidopsis (AtIVD). In animals, this homotetrameric enzyme is located in mitochondria and catalyzes the conversion of isovaleryl-CoA to 3-methylcrotonyl-CoA as an intermediate step in the leucine (Leu)
Tobias Bock et al.
Nucleic acids research, 45(4), 2166-2178 (2016-12-13)
Isovaleryl coenzyme A (IV-CoA) is an important building block of iso-fatty acids. In myxobacteria, IV-CoA is essential for the formation of signaling molecules involved in fruiting body formation. Leucine degradation is the common source of IV-CoA, but a second, de
Yu-Ning Liu et al.
Clinica chimica acta; international journal of clinical chemistry, 453, 13-20 (2015-12-02)
Propionyl-CoA carboxylase (PCC) is a mitochondrial enzyme involved in the catabolism of several essential amino acids and odd chain fatty acids. Previous PCC assays have involved either a radiometric assay or have required mitochondria isolation and/or enzyme purification. We developed
Helge B Bode et al.
Chembiochem : a European journal of chemical biology, 10(1), 128-140 (2008-10-11)
Isovaleryl-CoA (IV-CoA) is usually derived from the degradation of leucine by using the Bkd (branched-chain keto acid dehydrogenase) complex. We have previously identified an alternative pathway for IV-CoA formation in myxobacteria that branches from the well-known mevalonate-dependent isoprenoid biosynthesis pathway.
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