I9401
白介素1β 人
IL-1β, recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture
别名:
IL-1β, 淋巴细胞激活因子
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关于此项目
UNSPSC Code:
12352202
MDL number:
Biological source:
human
Recombinant:
expressed in E. coli
Assay:
≥98% (SDS-PAGE)
Form:
lyophilized powder
Mol wt:
17.3 kDa
biological source
human
recombinant
expressed in E. coli
assay
≥98% (SDS-PAGE)
form
lyophilized powder
potency
≤12 pg/mL ED50
quality
endotoxin tested
mol wt
17.3 kDa
packaging
pkg of 5 and 25 μg, pkg of 25 μg
technique(s)
cell culture | mammalian: suitable
color
white to off-white
UniProt accession no.
storage temp.
−20°C
Quality Level
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Biochem/physiol Actions
白介素-1 (IL-1)，最初称为淋巴细胞激活因子(LAF)，可激活T细胞淋巴细胞，进而增殖并分泌白介素-2 (IL-2)。IL-1主要从受刺激的巨噬细胞和单核细胞释放，但也已显示可从几种其他类型细胞中释放，并且被认为在炎症和免疫应答中起关键作用。IL-1的其他同义词包括：内源性热原(EP)、有丝分裂原蛋白(MP)、辅助峰-1 (lp -1)、T细胞替代因子III（TRF III或TRFM）、B细胞激活因子(BAF)和B细胞分化因子(BDF)。两种关系紧密的试剂白细胞介素-1 α(IL-1α)和白细胞介素-1β (IL-1β)在氨基酸序列上有62%的同源性，引起几乎相同的生物反应。IL-1α和IL-1β的糖基化量都在17 kDa左右，具有一定的异质性。
白介素-1可激活T细胞淋巴细胞，进而增殖并分泌白介素-2 (IL-2)。IL-1主要从受刺激的巨噬细胞和单核细胞释放，但也已显示可从几种其他类型细胞中释放，并且被认为在炎症和免疫应答中起关键作用。
Physical form
从0.2μm过滤的缓冲溶液中冻干。
Analysis Note
其生物活性是通过鼠D10S细胞对MTS切割的剂量依赖性刺激来进行测定的。
存储类别
13 - Non Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
法规信息
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