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安全信息

I9529

Sigma-Aldrich

Interleukin-10/Fc Chimera (non-lytic) from mouse

>98% (SDS-PAGE), recombinant, expressed in CHO cells, buffered aqueous solution

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别名:
IL-10:Fc (non-lytic)
MDL编号:
MFCD03457244
NACRES:
NA.32

生物来源

mouse

质量水平

200

重组

expressed in CHO cells

检测方案

>98% (SDS-PAGE)

形式

buffered aqueous solution

分子量

98 kDa

包装

pkg of 10 μg

杂质

endotoxin, tested

UniProt登记号

P18893

运输

wet ice

储存温度

−20°C

基因信息

mouse ... Il10(16153)

生化/生理作用

IL-10 (interleukin-10) is an anti-inflammatory cytokine. High levels of IL-10 are present in late syphilis. It is secreted by monocytes and lymphocytes. It suppresses Th1 (T helper) cytokines. IL-10 also controls the differentiation and proliferation of T cells, B cells, natural killer cells, antigen-presenting cells and mast cells.
Possesses the biological function of the IL-10 moiety and a prolonged circulating half-life determined by the Fc domain.

其他说明

Dimeric fusion protein consisting of mouse IL-10 fused to mutant mouse IgG2a Fc.

外形

Solution in 0.2 μm filtered phosphate buffered saline, pH 7.4.

储存分类代码

10 - Combustible liquids

WGK

WGK 2

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

法规信息

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Maciej Pastuszczak et al.
Human immunology, 76(7), 469-472 (2015-06-24)
Interleukin 10 (IL-10) is a potent anti-inflammatory cytokine. Increased production of IL-10 has been found in late syphilis, presumably creating favorable conditions for bacteria persistence. Single-nucleotide polymorphisms (SNPs) within the promoter of IL-10 gene have been found to influence IL-10
Lucia Elena Alvarado-Arnez et al.
PloS one, 10(9), e0136282-e0136282 (2015-09-05)
Leprosy is a chronic infectious disease that depends on the interplay of several factors. Single nucleotide polymorphisms (SNPs) in host immune related genes have been consistently suggested as participants in susceptibility towards disease. Interleukin-10 (IL-10) is a crucial immunomodulatory cytokine
C Gérard et al.
The Journal of experimental medicine, 177(2), 547-550 (1993-02-01)
Because of its ability to efficiently inhibit in vitro cytokine production by activated macrophages, we hypothesized that interleukin (IL) 10 might be of particular interest in preventing endotoxin-induced toxicity. We therefore examined the effects of IL-10 administration before lipopolysaccharide (LPS)
Manal Mohamed Makhlouf et al.
Laboratory medicine, 45(3), 211-219 (2014-07-23)
Immune thrombocytopenic purpura (ITP) is an acquired autoimmune disorder caused by the production of antiplatelet antibodies. These autoantibodies opsonize platelets for splenic clearance, resulting in low levels of circulating platelets. Interleukin 4 (IL4) and interleukin 10 (IL10) are important immunoregulatory

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