Monoclonal Anti-Insulin-like Growth Factor-II antibody produced in rat

purified, E. coli-derived recombinant mouse insulin-like growth factor-II.

Insulin-like growth factors -I and -II are important regulators of signaling that mediates growth and metabolism in cells. Insulin-like growth factor -II (IGF-II) is widely expressed during embryonic stages and regulates the placental development. IGF-II acts via specific receptor, IGF-IIR, the binding does not result in signal transduction, but is a mechanism to restrict the bioavailability of IGF-II. The effects of IGF-II signaling are important in growth of blood vessels (angiogenesis) gene transcription, proliferation and transformation.

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline containing carbohydrates.

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