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Merck
CN

I9759

Sigma-Aldrich

L-异亮氨酰-L-脯氨酰-L-异亮氨酸

≥97% (HPLC), Dipeptidyl peptidase IV inhibitor, powder

别名:

抑二肽素 A

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关于此项目

经验公式(希尔记法):
C17H31N3O4
化学文摘社编号:
分子量:
341.45
MDL编号:
UNSPSC代码:
51111800
PubChem化学物质编号:
NACRES:
NA.77
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产品名称

L-异亮氨酰-L-脯氨酰-L-异亮氨酸, ≥97% (HPLC)

质量水平

方案

≥97% (HPLC)

表单

powder

溶解性

water: 1 mg/mL, clear, colorless

储存温度

−20°C

SMILES字符串

CCC(C)C(N)C(=O)N1CCCC1C(=O)NC(C(C)CC)C(O)=O

InChI

1S/C17H31N3O4/c1-5-10(3)13(18)16(22)20-9-7-8-12(20)15(21)19-14(17(23)24)11(4)6-2/h10-14H,5-9,18H2,1-4H3,(H,19,21)(H,23,24)

InChI key

JNTMAZFVYNDPLB-UHFFFAOYSA-N

Amino Acid Sequence

Ile-Pro-Ile

应用

Ile-Pro-Ile 已被用作采血补充剂,用于测定激素 ,另外还用于稳定岛细胞培养物中的类胰升糖素肽1(GLP-1)。它还被用于抑制血清采集后促性腺激素抑制激素(GnIH)的分解。

生化/生理作用

二肽基肽酶 IV 抑制剂。抑制 HIV-1 或 HIV-2 的进入
二肽基肽酶 IV 的抑制剂。抑制 HIV-1 或 HIV-2 进入 T 淋巴母细胞样和单核细胞样细胞系。

特点和优势

该化合物是受体分类及信号转导手册上神经肽酶页面上的特色化合物。想要浏览手册的其他页面, 请单击此处

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)


历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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访问文档库

Pancreatic alpha cell-derived glucagon-related peptides are required for beta cell adaptation and glucose homeostasis
Traub S, et al.
Cell Reports, 18(13), 3192-3203 (2017)
Pádraigín A Harnedy et al.
Food research international (Ottawa, Ont.), 106, 598-606 (2018-03-28)
Large quantities of low-value protein rich co-products, such as salmon skin and trimmings, are generated annually. These co-products can be upgraded to high-value functional ingredients. The aim of this study was to assess the antidiabetic potential of salmon skin gelatin
Brandon L Panaro et al.
Molecular metabolism, 19, 65-74 (2018-11-28)
Fibroblast Activation Protein (FAP), an enzyme structurally related to dipeptidyl peptidase-4 (DPP-4), has garnered interest as a potential metabolic drug target due to its ability to cleave and inactivate FGF-21 as well as other peptide substrates. Here we investigated the
Gemma Pujadas et al.
Molecular metabolism, 39, 101008-101008 (2020-05-12)
Glucose-dependent insulinotropic polypeptide (GIP) conveys information from ingested nutrients to peripheral tissues, signaling energy availability. The GIP Receptor (GIPR) is also expressed in the bone marrow, notably in cells of the myeloid lineage. However, the importance of gain and loss
Effect of gonadotropin-inhibitory hormone on luteinizing hormone secretion in humans
George JT, et al.
Clinical Endocrinology, 86(5), 731-738 (2017)

商品

Bioactive small molecules for immune system signaling target identification/validation and antibiotics, antivirals, and antifungals offered.

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