I9890
m-碘苄胍 半硫酸盐
≥98% (HPLC and TLC), ADP ribosylation inhibitor
别名:
MIBG
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关于此项目
线性分子式:
C8H10IN3 · 1/2H2SO4
化学文摘社编号:
分子量:
324.13
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.77
产品名称
m-碘苄胍 半硫酸盐, ≥98% (HPLC and TLC)
质量水平
方案
≥98% (HPLC and TLC)
杂质
<0.5% Free iodobenzylamine
储存温度
2-8°C
SMILES字符串
OS(O)(=O)=O.NC(=N)NCc1cccc(I)c1.NC(=N)NCc2cccc(I)c2
InChI
1S/2C8H10IN3.H2O4S/c2*9-7-3-1-2-6(4-7)5-12-8(10)11;1-5(2,3)4/h2*1-4H,5H2,(H4,10,11,12);(H2,1,2,3,4)
InChI key
XNACDNPGABUBFR-UHFFFAOYSA-N
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相关类别
生化/生理作用
一种抑制ADP核糖基化的抗肿瘤药。
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Yunlong Zan et al.
Molecular imaging, 14, 373-384 (2015-07-15)
The objective of this work was to evaluate the sympathetic nervous system and structure remodeling during the progression of heart failure in a rodent model using dynamic cardiac single-photon emission computed tomography (SPECT). The spontaneously hypertensive rat (SHR) model was
L A Smets et al.
Cancer chemotherapy and pharmacology, 21(1), 9-13 (1988-01-01)
Meta-iodo-benzylguanidine (MIBG) is an analogue of the neurotransmitter norepinephrine. In its radioiodinated form, MIBG is clinically used as a tumor-targeted radiopharmaceutical in the diagnosis and treatment of adrenergic tumors. The potential cytotoxicity of the unlabeled drug was tested. MIBG appeared
Sylvie Slaets et al.
International journal of geriatric psychiatry, 30(8), 864-869 (2014-11-05)
Iodine-123 metaiodobenzylguanidine (MIBG) cardiac scintigraphy has shown the potential to discriminate dementia with Lewy bodies (DLB) from Alzheimer's disease (AD). However, these studies did not reflect clinical practice, as patients with ischemic heart disease, heart failure, diabetes mellitus, arterial hypertension
C Loesberg et al.
Biochimica et biophysica acta, 1037(1), 92-99 (1990-01-19)
Meta-iodobenzylguanidine (MIBG) is a guanidine analogue of the neurotransmitter norepinephrine. Radioiodinated [131I]MIBG is clinically used as a tumor-targeted radiopharmaceutical in the diagnosis and treatment of adrenergic tumors. Moreover, non-radiolabelled MIBG exerts several cell-biological effects, tentatively ascribed to interference with cellular
Yan Su et al.
International journal of molecular medicine, 34(3), 842-848 (2014-06-28)
The aim of the present study was to investigate the effects of meta-iodobenzylguanidine (MIBG) on the invasive properties of hepatocellular carcinoma (HCC) cells and examine whether these effects are due to the ability of MIBG to inhibit arginine-specific mono-ADP-ribosylation. Samples
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