J3580
JNJ 17203212
≥98% (HPLC)
别名:
N1-(3-Trifluoromethylpyrid-2-yl)-N4-(4-trifluoromethylpyrid-2-yl)carbamoylpiperazine
方案
≥98% (HPLC)
表单
powder
颜色
white to off-white
溶解性
DMSO: >20 mg/mL
创始人
Johnson & Johnson
储存温度
−20°C
SMILES字符串
FC(F)(F)c1c(nccc1)N2CCN(CC2)C(=O)Nc3ncc(cc3)C(F)(F)F
InChI
1S/C17H15F6N5O/c18-16(19,20)11-3-4-13(25-10-11)26-15(29)28-8-6-27(7-9-28)14-12(17(21,22)23)2-1-5-24-14/h1-5,10H,6-9H2,(H,25,26,29)
InChI key
JFRYYGVYCWYIDQ-UHFFFAOYSA-N
生化/生理作用
JNJ 17203212 is a reversible, competitive and potent TRPV1 antagonist that does not inhibit related TRP channels such as TRPV2, TRPV4, or TRPA1. Listed in BJP with IC50= 65 nM. TRPV1 channels are activated by heat, capsaicin and the endocannabinoid anandamide. Interest in TRPV1 antagonists in the transmission and modulation of pain.
JNJ 17203212 is a reversible, competitive and potent TRPV1 antagonist.
特点和优势
This compound was developed by Johnson & Johnson. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
警示用语：
Danger
危险声明
危险分类
Acute Tox. 3 Oral - Eye Irrit. 2
储存分类代码
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
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