主要文件

查看所有文档

J3770

JNJ7777120

Name: JNJ7777120
Brand: SIGMA

≥98% (HPLC), histamine receptor antagonist, solid

别名:

1-[(5-Chloro-1H-indol-2-yl)carbonyl]-4-methyl-piperazine

登录并加购，请在购物车里查看协议价、货期和发货地。

选择规格

变更视图

关于此项目

经验公式（希尔记法）:

C₁₄H₁₆N₃OCl

化学文摘社编号:

459168-41-3

分子量:

277.75

UNSPSC Code:

12352200

PubChem Substance ID:

329815408

NACRES:

NA.77

MDL number:

MFCD04343337

Assay:

≥98% (HPLC)

Form:

solid

技术服务

需要帮助？我们经验丰富的科学家团队随时乐意为您服务。

让我们为您提供帮助

属性

产品名称

JNJ7777120, ≥98% (HPLC)

Quality Segment

100

assay

≥98% (HPLC)

form

solid

color

white to off-white

solubility

DMSO: >20 mg/mL, H₂O: insoluble

originator

Johnson & Johnson

storage temp.

room temp

SMILES string

CN1CCN(CC1)C(=O)c2cc3cc(Cl)ccc3[nH]2

InChI

1S/C14H16ClN3O/c1-17-4-6-18(7-5-17)14(19)13-9-10-8-11(15)2-3-12(10)16-13/h2-3,8-9,16H,4-7H2,1H3

InChI key

HUQJRYMLJBBEDO-UHFFFAOYSA-N

说明

Application

JNJ7777120 has been used as a histamine-4 receptor antagonist:

to study its effects on the pro-inflammatory microglia in rats
to study its effects on the Parkinson′s-like pathology in rat brain
to study its effects on the histamine receptor interaction in periodontal ligament fibroblasts (PDLF)

Biochem/physiol Actions

JNJ7777120 may exhibit neuroprotective effects against ischemic brain damage. It acts as an anti-inflammatory agent to treat inflammatory diseases. JNJ7777120 is observed to reduce colonic injury, cytokine production, and neutrophil infiltration.

JNJ7777120 is a potent, selective non-imidazole H₄ histamine receptor antagonist.

Features and Benefits

This compound is featured on the Histamine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Johnson & Johnson. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

象形图

GHS07

警示词

Warning

危险代码

H315,H319,H335

预防性声明

P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

靶器官

Respiratory system

存储类别

11 - Combustible Solids

怎么回事？

WGK 3

闪点 (F)

Not applicable

闪点 (°C)