J4137
JS-K
≥97%, Nitric oxide donor
别名:
O2-（2,4-二硝基苯基）1-[（（4-乙氧基羰基）哌嗪-1-基]重氮-1-1,2-二醇酯
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关于此项目
经验公式（希尔记法）:
C13H16N6O8
化学文摘社编号:
分子量:
384.30
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
产品名称
JS-K, ≥97%
SMILES string
CCOC(=O)N1CCN(CC1)\[N+]([O-])=N\Oc2ccc(cc2[N+]([O-])=O)[N+]([O-])=O
InChI
1S/C13H16N6O8/c1-2-26-13(20)15-5-7-16(8-6-15)19(25)14-27-12-4-3-10(17(21)22)9-11(12)18(23)24/h3-4,9H,2,5-8H2,1H3/b19-14-
InChI key
DNJRNBYZLPKSHV-RGEXLXHISA-N
assay
≥97%
storage condition
desiccated
solubility
DMSO: soluble 9.3 mg/mL, H2O: insoluble
shipped in
dry ice
storage temp.
−20°C
Quality Level
相关类别
Biochem/physiol Actions
一氧化氮供体；抗增殖。
JS-K属于二醇二氮烯鎓前药的类别。当被谷胱甘肽S-转移酶（GST）代谢时，它会生成一氧化氮，从而确保了JS-K的最佳活性。它在人类前列腺癌和白血病中具有抑制肿瘤生长的作用。
Legal Information
受美国专利号6,610,660保护
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Ray Dong et al.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 88, 367-373 (2017-01-26)
JS-K is a novel anticancer nitric oxide (NO) prodrug effective against a variety of cancer cells, including the inhibition of AM-1 hepatoma cell growth in rats. To further evaluate anticancer effects of JS-K, human hepatoma Hep3B cells were treated with
Martin Laschak et al.
BMC cancer, 12, 130-130 (2012-04-03)
Nitric oxide (NO) and its oxidative reaction products have been repeatedly shown to block steroid receptor function via nitrosation of zinc finger structures in the DNA-binding domain (DBD). In consequence NO-donors could be of special interest for the treatment of
Bin Liu et al.
BMC cancer, 19(1), 645-645 (2019-07-03)
Ovarian cancer (OC) is the second most frequent gynecological cancer and is associated with a poor prognosis because OC progression is often asymptoma-tic and is detected at a late stage. There remains an urgent need for novel targeted therapies to
JS-K, a GST-activated nitric oxide generator, induces DNA double-strand breaks, activates DNA damage response pathways, and induces apoptosis in vitro and in vivo in human multiple myeloma cells
Kiziltepe T, et al.s
Blood, 110(2), 709-718 (2007)
Rui Zhang et al.
Macromolecular bioscience, 16(1), 121-128 (2015-07-30)
There is a need for new treatment strategies of acute myeloid leukemia (AML). In this study, four different drugs, including cytarabine, daunorubicin, GDC-0980, and JS-K, were investigated in vitro for the two-drug combinations treatment of AML. The results revealed that
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