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J4145

Sigma-Aldrich

介藜芦胺

≥98% (HPLC), powder

别名:

(3β, 23β)-17,23-Epoxy-3-hydroxyveratraman-11-one, 11-Ketocyclopamine

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1 MG
CN¥1,503.94

关于此项目

经验公式（希尔记法）:
C27H39NO3
化学文摘社编号:
469-59-0
分子量:
425.60
EC 号:
207-417-9
MDL编号:
MFCD01684066
UNSPSC代码:
51111800
PubChem化学物质编号:
24896194
NACRES:
NA.77

CN¥1,503.94

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方案

≥98% (HPLC)

表单

powder

溶解性

methanol: >2 mg/mL
H2O: insoluble

储存温度

−20°C

SMILES字符串

[H][C@@]12C[C@H](C)CN[C@@]1([H])[C@@H](C)[C@@]3(CC[C@]4([H])C(=C3C)C(=O)[C@@]5([H])[C@@]4([H])CC=C6C[C@@H](O)CC[C@]56C)O2

InChI

1S/C27H39NO3/c1-14-11-21-24(28-13-14)16(3)27(31-21)10-8-19-20-6-5-17-12-18(29)7-9-26(17,4)23(20)25(30)22(19)15(27)2/h5,14,16,18-21,23-24,28-29H,6-13H2,1-4H3/t14-,16+,18-,19-,20-,21+,23+,24-,26-,27-/m0/s1

InChI key

CLEXYFLHGFJONT-DNMILWOZSA-N

基因信息

human ... EBP(10682)

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C4116420210PHL83515
Jervine ≥98% (HPLC), powder

Sigma-Aldrich

J4145

Jervine

Cyclopamine hydrate ≥98% (HPLC)

Sigma-Aldrich

C4116

Cyclopamine hydrate

Jervine A cell-permeable steroidal alkaloid similar to cyclopamine that displays teratogenic effects and induces cyclopia by blocking Sonic Hedgehog signaling.

Sigma-Aldrich

420210

Jervine

Jervine phyproof® Reference Substance

PHL83515

Jervine

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥95.0% (HPLC)

form

powder

form

solid

form

solid

form

-

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

-

storage temp.

−20°C

storage temp.

2-8°C

storage temp.

−20°C

storage temp.

2-8°C

solubility

methanol: >2 mg/mL, H2O: insoluble

solubility

DMSO: soluble ≥5 mg/mL, H2O: insoluble

solubility

ethanol: 10 mg/mL, DMSO: 5 mg/mL

solubility

-

Gene Information

human ... EBP(10682)

Gene Information

human ... EBP(10682)

Gene Information

-

Gene Information

-

一般描述

Jervine is a steroid alkaloid present in Veratrum californicum.[1][2]

生化/生理作用

Jervine is a potent teratogenic agent.[3] It can induce apoptosis in leukemia cells[1] and MUTZ-1 cells. Jervine is an inhibitor of Hedgehog signaling. It exhibits anti-cancer effects on human prostate cancer. It also increases the chemosensitivity of breast cancer cells to doxorubicin treatment.[2] Jervine may be used for treating hypertension and heart disease.[3]
Jervine is a sonic hedgehog (Shh) pathway inhibitor.

象形图

Skull and crossbonesHealth hazard
GHS06,GHS08

警示用语：

Danger

危险声明

H301,H360D

危险分类

Acute Tox. 3 Oral - Repr. 1B

储存分类代码

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 1

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

法规信息

新产品
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    • 历史批次信息供参考:

    分析证书(COA)

    Lot/Batch Number
    062M4709V
    081M4727V
    019K4707
    057K4710
    104K4703

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    M Campbell et al.
    Teratology, 36(2), 235-243 (1987-10-01)
    Jervine and retinoic acid are both teratogenic to structures which are initially modelled in cartilage. Differences in periods of maximal sensitivity, as well as in certain aspects of the morphological manifestations of exposure, indicate that these two teratogens act via
    L K Bechtel et al.
    Clinical toxicology (Philadelphia, Pa.), 48(5), 435-442 (2010-07-01)
    We report a case of digoxin-like toxicity because of ingestion of foraged plants. This patient presented with nausea, vomiting, bradycardia, and hypotension after ingesting Veratrum viride (false hellebore). The patient's serum specimen demonstrated a positive digoxin level (0.38 ng/mL) measured
    H Li et al.
    Acta pharmacologica Sinica, 21(1), 23-28 (2001-03-27)
    To study the central hypotensive mechanism of Veratrum nigrum L var ussurience Nakai alkaloids (VnA) in renal hypertensive rats(RHR). The quantitative method of immunocytochemistry (ICC) was used to observe and detect the effect of VnA (30 micrograms.kg-1, i.v.) on activity
    Stephen T Lee et al.
    Journal of agricultural and food chemistry, 51(3), 582-586 (2003-01-23)
    Veratrum californicum was responsible for large losses of sheep grazing high mountain ranges in central Idaho in the 1950s. Veratrum induces various birth defects including the cyclopic-type craniofacial defect (monkey-faced lambs) that is specifically induced in lambs after pregnant ewes
    D L Young et al.
    Critical reviews in oral biology and medicine : an official publication of the American Association of Oral Biologists, 11(3), 304-317 (2000-10-06)
    Craniofacial malformations are the most common birth defects that occur in humans, with facial clefting representing the majority of these defects. Facial clefts can arise at any stage of development due to perturbations that alter the extracellular matrix as well
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