K0253
角蛋白 来源于人表皮
aqueous solution
产品名称
角蛋白 来源于人表皮, aqueous solution
biological source
human epidermis
assay
≥90% (SDS-PAGE)
form
urea solution
technique(s)
ELISA: suitable
UniProt accession no.
storage temp.
2-8°C
Quality Level
Gene Information
human ... KRT1(3848)
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Application
人表皮角蛋白已用于：
- 在固相抗体芯片中作为分析物和交叉反应剂用于测定选择系数
- 作为细胞外基质(ECM)蛋白标准品进行体外蛋白降解分析
- 作为酶联免疫吸附测定(ELISA)的标准品
Biochem/physiol Actions
角蛋白对于上皮细胞和组织的机械稳定性和完整性非常重要。一些角蛋白还具有调节功能，并可参与细胞内信号转导途径，例如对压力的保护、伤口愈合和细胞凋亡。这组多样化的细胞骨架支架蛋白可形成中等细丝网络，其为维持皮肤完整性的角质形成细胞提供了结构支持。角蛋白基因的表达通常受分层鳞状上皮细胞内表皮细胞分化的调节。
General description
角蛋白是上皮组织的标志性中间纤维蛋白。在人类中，角蛋白分为I型和II型。约有54个基因编码角蛋白。角蛋白1（KRT1）基因被定位到人类染色体12q13.13上。它是头发、皮肤和指甲的主要成分。
Physical form
溶于 8 M 尿素、50 mM Tris、0.1 M β-巯基乙醇和 0.1% 叠氮化钠，pH 8.4
signalword
Warning
hcodes
Hazard Classifications
Skin Sens. 1
存储类别
10 - Combustible liquids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
此项目有
Keratin-based Biomaterials and Bioproducts, 5-5 (2017)
Comparison of biomarkers in exhaled breath condensate and bronchoalveolar lavage
Jackson AS, et al.
American Journal of Respiratory and Critical Care Medicine, 175(3), 222-227 (2007)
A Pena et al.
Optics express, 13(17), 6667-6667 (2005-08-22)
We present corrected versions of the list of authors and of Section 2.1.
Christopher J Day et al.
PLoS neglected tropical diseases, 15(2), e0009136-e0009136 (2021-02-26)
Mycobacterium ulcerans is the causative agent of the chronic, necrotizing skin disease Buruli ulcer. Modes of transmission and molecular mechanisms involved in the establishment of M. ulcerans infections are poorly understood. Interactions with host glycans are often crucial in bacterial
Christian Mozet et al.
Anticancer research, 33(6), 2415-2424 (2013-06-12)
The hedgehog signaling pathway (HH) is involved in tumorigenesis in a variety of human malignancies. In head and neck squamous cell carcinomas (HNSCC), Hh overexpression was associated with poor prognosis. Therefore, we analyzed the effect of Hh signaling blockade with
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