K0265
Anti-Potassium Channel K2P4.1 (TRAAK) 兔抗
affinity isolated antibody, lyophilized powder
别名:
Anti-KCNK4, Anti-TWIK-related arachidonic acid-stimulated K+ channel
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
lyophilized powder
species reactivity
human, rat
technique(s)
immunohistochemistry: suitable, western blot: 1:200 using HEK-K2P4.1 transfected cells or rat cerebellum lysate
UniProt accession no.
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... KCNK4(50801)
rat ... Kcnk4(116489)
General description
The gene K2P4.1, also referred to as KCNK4 (potassium two pore domain channel subfamily K member 4), encodes a protein belonging to the subfamily of K2P (two pore domain K+ channel) channels called TRAAK (TWIK-related arachidonic acid-stimulated K+ channel). The TRAAK channels are expressed selectively in the nervous system. TRAAK channel contains two protomers, each with two distinct pore domains forming a two-fold symmetric potassium channel.
Immunogen
peptide NLAFIDESSDTQSERGC, corresponding to amino acid residues 343-359 of human K2P4.1.
Biochem/physiol Actions
The K2P4.1 antibody is directed against a highly conserved epitope in the intraracellular C-terminal region of the human K2P4.1 channel.
The gene KCNK4 (potassium two pore domain channel subfamily K member 4) encodes a potassium channel that is mechanosensitive and is regulated by polyunsaturated fatty acids and temperature. The structure and chemical composition of the lipid bilayer has a profound effect on the functioning of this K+ channel. It is found to regulate the noxious input threshold in dorsal root ganglia neurons.
Physical form
Lyophilized powder from phosphate buffered saline, pH 7.4, containing 1% BSA and 0.025% sodium azide.
Preparation Note
Reconstitute the lyophilized vial with 50 μL or 200 μL deionized water, depending on package size. Further dilutions should be made using a carrier protein, such as BSA (1-3%).
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
未找到合适的产品？
试试我们的产品选型工具.
存储类别
10 - Combustible liquids
wgk
nwg
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
Trichloroethanol enhances the activity of recombinant human TREK-1 and TRAAK channels.
Harinath S and Sikdar SK
Neuropharmacology, 46, 750-760 (2004)
Crystal structure of the human K2P TRAAK, a lipid- and mechano-sensitive K+ ion channel.
Brohawn SG
Science, 335, 436-441 (2012)
相关内容
Instructions
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系客户支持