Anti-Potassium Channel Kv12.1 (Elk1) 兔抗

K_v12.1 channel is confined mainly to the central nervous system with some expression in peripheral organs such as testis, colon and lung. The physiological function of the K_v12.1 channel hasn′t been established, although a role in the modulation of overall excitability of neurons has been suggested.

The gene Kcnh8 (potassium voltage-gated channel subfamily H member 8), also referred to as Elk1/Ets-1, belongs to the Ets family of transcription factors. The members of this subfamily are part of the ether-a-go-go (EAG) family of potassium channel pore-forming subunits. The rat elk mRNA is found to be expressed in brain. The rat elk subunits contain six hydrophobic membrane-spanning segments S1-S6, a P-domain, and a motif homologous to cyclic nucleotide-binding domains at the C-terminus.

peptide EDKKEDRAKGRSRAG(C) corresponding to amino acid residues 143-157 of rat K_V12.1.

The gene Kcnh8 (potassium voltage-gated channel subfamily H member 8) encodes a potassium channel pore-forming subunit that activates p21WAF1/Cip1 via cis-acting elements in p21WAF1/Cip1 and inhibits apoptosis of vascular smooth muscle cells. The potassium channel is found to mediate slowly activating sustained potassium currents.

Lyophilized from phosphate buffered saline, pH 7.4, containing 1% BSA and 0.025% sodium azide.

Reconstitute the lyophilized vial with 50 μL or 200 μL deionized water, depending on package size. Further dilutions should be made using a carrier protein such as BSA (1-3%).

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