产品名称
Anti-Potassium Channel KV11.3 (erg3) 兔抗, affinity isolated antibody, lyophilized powder
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
lyophilized powder
species reactivity
mouse, human, rat
technique(s)
immunohistochemistry: suitable using rat brain sections
western blot: 1:300 using rat brain lysates
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... KCNH7(90134)
mouse ... Kcnh7(170738)
rat ... Kcnh7(170739)
Biochem/physiol Actions
The KV11.3 antibody is directed against an intracellular epitope of C-terminal part of KV11.3.
The gene Kcnh7 (potassium voltage-gated channel subfamily H member 7) encodes a voltage gated K+ channel that modulates the membrane potential in its rested and activated state. In the nervous system, it may participate in the regulation of neuronal excitability. The erg3 channels have relatively negative activation threshold compared to erg1 and erg2. They are capable of recycling K+ ions to the subretinal space in the dark and contribute to the maintenance of the resting membrane potential.
General description
The gene Kcnh7 (potassium voltage-gated channel subfamily H member 7), also referred to as erg3, encodes a subunit of ether-à-go-go related (erg) K+ channels. The erg K+ channels are part of the EAG (ether-à-go-go) family of voltage-gated K+ channels. The encoded protein is found to be expressed in the apical membrane of the retinal pigment epithelium.
Immunogen
synthetic peptide CPEFLDLEKSKLKSKE corresponding to amino acids 1108-1123 of rat KV11.3.
Physical form
Lyophilized powder containing phosphate buffered saline, pH 7.4, 1% BSA and 0.025% sodium azide.
Preparation Note
Reconstitute the lyophilized vial with 50 μL or 200 μL deionized water, depending on package size. Further dilutions should be made using a carrier protein such as BSA (1-3%).
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存储类别
10 - Combustible liquids
法规信息
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此项目有
Functional properties of human neuronal Kv11 channels.
Einarsen K
Pflugers Archiv : European Journal of Physiology, 458, 689-700 (2009)
Sönke Cordeiro et al.
PloS one, 6(12), e29490-e29490 (2011-12-30)
In response to light, most retinal neurons exhibit gradual changes in membrane potential. Therefore K+ channels that mediate threshold currents are well-suited for the fine-tuning of signal transduction. In the present study we demonstrate the expression of the different Kv11
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