K1128
α-酮戊二酸
BioReagent, suitable for cell culture, suitable for insect cell culture
别名:
2-氧代戊二酸, 2-氧化戊二酸
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关于此项目
线性分子式:
HOOCCH2CH2COCOOH
化学文摘社编号:
分子量:
146.10
UNSPSC Code:
12352204
NACRES:
NA.32
PubChem Substance ID:
EC Number:
206-330-3
Beilstein/REAXYS Number:
1705689
MDL number:
产品名称
α-酮戊二酸, BioReagent, suitable for cell culture, suitable for insect cell culture
InChI key
KPGXRSRHYNQIFN-UHFFFAOYSA-N
InChI
1S/C5H6O5/c6-3(5(9)10)1-2-4(7)8/h1-2H2,(H,7,8)(H,9,10)
SMILES string
OC(=O)CCC(=O)C(O)=O
product line
BioReagent
assay
≥98.5% NaOH basis (titration)
form
powder or crystals
technique(s)
cell culture | insect: suitable
cell culture | mammalian: suitable
solubility
water: 100 mg/mL, clear to slightly hazy, colorless to almost colorless
storage temp.
2-8°C
Quality Level
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Application
α--酮戊二酸已用于：
- 作为最低基础培养基α (α-MEM)的补充剂，培养原代间充质基质细胞/干细胞 (MSC)， 以研究其对年龄相关性骨质疏松症的影响
- 化学治疗，以在手动和自动寿命机器 (ALM) 平台之间，比较几种化合物对寿命的治疗效果
- 用作打印趋化因子配体，使用高通量技术筛选趋化因子受体并验证与表面等离子体共振 (SPR) 的相互作用
Biochem/physiol Actions
α-酮戊二酸(αKG)是一种氮清除剂，是谷氨酸和谷氨酰胺的重要来源。它负责控制ATP合成并减少三羧酸 (TCA) 循环中的等价物 (NAD+/NADH) 生成。它可促进蛋白质合成，防止肌肉中的蛋白质降解。这种免疫营养因子参与一般免疫和胶原蛋白代谢。在老年啮齿动物中，αKG可加速骨缺损愈合，可能具有潜在抗衰老作用。这种Krebs循环分子可用作昆虫和哺乳动物细胞培养的补充剂。
General description
α-酮戊二酸(αKG)是三羧酸 (TCA)/Krebs循环中的琥珀酰辅酶 A 和异柠檬酸之间重要的中间产物。
signalword
Danger
hcodes
Hazard Classifications
Eye Dam. 1
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
Nan Wu et al.
Biomolecules & therapeutics, 24(1), 1-8 (2016-01-14)
Alpha-ketoglutarate (AKG) is a key molecule in the Krebs cycle determining the overall rate of the citric acid cycle of the organism. It is a nitrogen scavenger and a source of glutamate and glutamine that stimulates protein synthesis and inhibits
J Kitaura et al.
European journal of pediatrics, 158(5), 410-413 (1999-05-20)
Two cases of hyperinsulinaemic hypoglycaemia associated with persistent hyperammonaemia in unrelated infants of 7 days and 4 months of age are reported. Blood ammonia levels were 100-300 micromol/l (normal values <40 micromol/l). The hyperammonaemia was asymptomatic and not associated with
Yuan Wang et al.
Nature communications, 11(1), 5596-5596 (2020-11-07)
Age-related osteoporosis is characterized by the deterioration in bone volume and strength, partly due to the dysfunction of bone marrow mesenchymal stromal/stem cells (MSCs) during aging. Alpha-ketoglutarate (αKG) is an essential intermediate in the tricarboxylic acid (TCA) cycle. Studies have
Christopher J Day et al.
Methods in molecular biology (Clifton, N.J.), 1729, 303-317 (2018-02-13)
Ligand-receptor interactions triggering signal transduction components of many sensory pathways, remain elusive due to paucity of high-throughput screening methods. Here we describe our use of small molecule microarrays comprising of small glycans, amino and organic acids, salts, and other known
Kaiju Sun et al.
Theranostics, 11(12), 5831-5846 (2021-04-27)
Purpose: The implementation of targeted therapies for acute myeloid leukemia (AML) has been challenging. Fat mass and obesity associated protein (FTO), an mRNA N6-methyladenosine (m6A) demethylase, functions as an oncogene that promotes leukemic oncogene-mediated cell transformation and leukemogenesis. Here, we
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