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Merck
CN

K1140

Sigma-Aldrich

Kifunensine

solid,film or powder, ≥98%

别名:

FR 900494, 六氢6R，7S，8aS-三羟基-5R-（羟甲基）-咪唑并[1,2-a]吡啶-2,3-二酮

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关于此项目

经验公式（希尔记法）:
C8H12N2O6
CAS Number:
109944-15-2
分子量:
232.19
UNSPSC代码:
12352204
NACRES:
NA.77

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Product Name

Kifunensine, mannosidase inhibitor

生物来源

synthetic (organic)

质量水平

100

方案

≥98%

表单

film or powder
solid

溶解性

water, double-distilled: 50 mM

储存温度

−20°C

SMILES字符串

N21[C@H](NC(=O)C2=O)[C@H]([C@H]([C@@H]([C@H]1CO)O)O)O

InChI

1S/C8H12N2O6/c11-1-2-3(12)4(13)5(14)6-9-7(15)8(16)10(2)6/h2-6,11-14H,1H2,(H,9,15)/t2-,3-,4+,5+,6+/m1/s1

InChI key

OIURYJWYVIAOCW-PQMKYFCFSA-N

基因信息

human ... MAN1A1(4121), MAN1A2(10905), MAN1B1(11253), MAN1C1(57134)
mouse ... MAN1A1(17155), MAN1A2(17156), MAN1B1(227619), MAN1C1(230815)
rat ... MAN1A1(294410), MAN1A2(295319), MAN1B1(499751), MAN1C1(362625)

一般描述

Kifunensine是一种生物碱化合物，从放线菌Kitasporia kifunensis中分离出来。

应用

Kifunensine已用作Jurkat T细胞、人胚胎肾脏（HEK293T / 17）细胞和小鼠胚胎成纤维细胞中的甘露糖苷酶I抑制剂。

生化/生理作用

Kifunensine是一类糖蛋白加工甘露糖苷酶的选择性抑制剂。
Kifunensine通过抑制内质网相关的甘露糖苷酶的活性来抑制内质网相关的降解(ERAD)。它也是I类CAZy糖基水解酶家族47的糖苷酶抑制剂。

象形图

Exclamation mark
GHS07

警示用语：

Warning

危险声明

H319

危险分类

Eye Irrit. 2

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)

法规信息

监管及禁止进口产品

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
MKCX7765
MKCX0619
MKCW5200
MKCW1806
MKCT9978

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eLife, 9 (2020-03-04)
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N-glycosylation of asparagine 8 regulates surface expression of major histocompatibility complex class I chain-related protein A (MICA) alleles dependent on threonine 24
Mellergaard M, et al.
The Journal of Biological Chemistry, 289(29), 20078-20091 (2014)
Qun Zhou et al.
Biotechnology and bioengineering, 99(3), 652-665 (2007-08-08)
Glycosylation in the Fc region of antibodies has been shown to play an important role in antibody function. In the current study, glycosylation of human monoclonal antibodies was metabolically modulated using a potent alpha-mannosidase I inhibitor, kifunensine, resulting in the
Mohsan Saeed et al.
The Journal of biological chemistry, 286(43), 37264-37273 (2011-09-01)
Viral infections frequently cause endoplasmic reticulum (ER) stress in host cells leading to stimulation of the ER-associated degradation (ERAD) pathway, which subsequently targets unassembled glycoproteins for ubiquitylation and proteasomal degradation. However, the role of the ERAD pathway in the viral
Christopher N Scanlan et al.
Journal of molecular biology, 372(1), 16-22 (2007-07-17)
The HIV envelope has evolved a dense array of immunologically "self" carbohydrates that efficiently protect the virus from antibody recognition. Nonetheless, one broadly neutralising antibody, IgG1 2G12, has been shown to recognise a cluster of oligomannose glycans on the HIV-1
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