产品名称
Kifunensine, mannosidase inhibitor
biological source
synthetic (organic)
Quality Level
assay
≥98%
form
film or powder, solid
solubility
water, double-distilled: 50 mM
storage temp.
−20°C
SMILES string
N21[C@H](NC(=O)C2=O)[C@H]([C@H]([C@@H]([C@H]1CO)O)O)O
InChI
1S/C8H12N2O6/c11-1-2-3(12)4(13)5(14)6-9-7(15)8(16)10(2)6/h2-6,11-14H,1H2,(H,9,15)/t2-,3-,4+,5+,6+/m1/s1
InChI key
OIURYJWYVIAOCW-PQMKYFCFSA-N
Gene Information
human ... MAN1A1(4121), MAN1A2(10905), MAN1B1(11253), MAN1C1(57134)
mouse ... MAN1A1(17155), MAN1A2(17156), MAN1B1(227619), MAN1C1(230815)
rat ... MAN1A1(294410), MAN1A2(295319), MAN1B1(499751), MAN1C1(362625)
General description
Kifunensine是一种生物碱化合物，从放线菌Kitasporia kifunensis中分离出来。
Application
Kifunensine已用作Jurkat T细胞、人胚胎肾脏（HEK293T / 17）细胞和小鼠胚胎成纤维细胞中的甘露糖苷酶I抑制剂。
Biochem/physiol Actions
Kifunensine是一类糖蛋白加工甘露糖苷酶的选择性抑制剂。
Kifunensine通过抑制内质网相关的甘露糖苷酶的活性来抑制内质网相关的降解(ERAD)。它也是I类CAZy糖基水解酶家族47的糖苷酶抑制剂。
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
法规信息
涉药品监管产品
此项目有
Yusuke Saijo et al.
The EMBO journal, 28(21), 3439-3449 (2009-09-19)
Pattern recognition receptors in eukaryotes initiate defence responses on detection of microbe-associated molecular patterns shared by many microbe species. The Leu-rich repeat receptor-like kinases FLS2 and EFR recognize the bacterial epitopes flg22 and elf18, derived from flagellin and elongation factor-Tu
N-glycosylation of mouse TRAIL-R restrains TRAIL-induced apoptosis
Estornes Y, et al.
Cell Death & Disease, 9(5), 494-494 (2018)
Andrew I Flyak et al.
eLife, 9 (2020-03-04)
A vaccine protective against diverse HCV variants is needed to control the HCV epidemic. Structures of E2 complexes with front layer-specific broadly neutralizing antibodies (bNAbs) isolated from HCV-infected individuals, revealed a disulfide bond-containing CDRH3 that adopts straight (individuals who clear
N-glycosylation of asparagine 8 regulates surface expression of major histocompatibility complex class I chain-related protein A (MICA) alleles dependent on threonine 24
Mellergaard M, et al.
The Journal of Biological Chemistry, 289(29), 20078-20091 (2014)
Christopher N Scanlan et al.
Journal of molecular biology, 372(1), 16-22 (2007-07-17)
The HIV envelope has evolved a dense array of immunologically "self" carbohydrates that efficiently protect the virus from antibody recognition. Nonetheless, one broadly neutralising antibody, IgG1 2G12, has been shown to recognise a cluster of oligomannose glycans on the HIV-1
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| K1140-1MG | 04061833867938 |
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