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Merck
CN

K1377

Sigma-Aldrich

卡那霉素 硫酸酯 来源于卡那霉素链霉菌

powder, BioReagent, suitable for cell culture, suitable for plant cell culture

别名:

卡那霉素 A, 卡那霉素碱 硫酸盐

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关于此项目

经验公式（希尔记法）:
C18H36N4O11 · H2O4S
化学文摘社编号:
25389-94-0
分子量:
582.58
EC 号:
246-933-9
MDL编号:
MFCD00070253
UNSPSC代码:
51281654
PubChem化学物质编号:
24896204
NACRES:
NA.76

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生物来源

Streptomyces kanamyceticus

质量水平

200

产品线

BioReagent

表单

powder

效能

≥750 μg per mg (dry basis)

技术

cell culture | mammalian: suitable
cell culture | plant: suitable

颜色

white to off-white

溶解性

H2O: 10-50 mg/mL (As a stock solution. Stock solutions should be stored at 2-8°C. Stable at 37°C for 5 days.)

抗生素抗菌谱

Gram-negative bacteria
Gram-positive bacteria
mycobacteria
mycoplasma

应用

agriculture

作用机制

protein synthesis | interferes

SMILES字符串

OS(O)(=O)=O.NC[C@H]1O[C@H](O[C@@H]2[C@@H](N)C[C@@H](N)[C@H](O[C@H]3O[C@H](CO)[C@@H](O)[C@H](N)[C@H]3O)[C@H]2O)[C@H](O)[C@@H](O)[C@@H]1O

InChI

1S/C18H36N4O11.H2O4S/c19-2-6-10(25)12(27)13(28)18(30-6)33-16-5(21)1-4(20)15(14(16)29)32-17-11(26)8(22)9(24)7(3-23)31-17;1-5(2,3)4/h4-18,23-29H,1-3,19-22H2;(H2,1,2,3,4)/t4-,5+,6-,7-,8+,9-,10-,11-,12+,13-,14-,15+,16-,17-,18-;/m1./s1

InChI key

OOYGSFOGFJDDHP-KMCOLRRFSA-N

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相关类别

一般描述

在生物技术中用于抑制蛋白质合成。建议以 100mg/L 的量用于细胞培养应用。
Chemical structure: aminoglycoside

应用

Kanamycin sulfate from Streptomyces kanamyceticus has been used in tissue culture media.

生化/生理作用

作用机制：该产品通过与70S核糖体亚基结合，抑制易位并引起错误编码而起作用。

耐药机制：氨基糖苷类修饰酶（包括乙酰转移酶、磷酸转移酶、核苷酸转移酶）可以改变这种抗生素，阻止其与核糖体相互作用。

抗菌谱：硫酸卡那霉素对革兰氏阴性和革兰氏阳性菌以及支原体有效。

制备说明

Kanamycin sulfate is soluble in water at 50 mg/mL, yielding a clear solution. It is practically insoluble in alcohol, acetone, chloroform, ether and ethyl acetate. A 1% solution in water has a pH of 6.5 to 8.5. Sterile solutions can be prepared by a sterile filtration, through a .2μm filter.

免责声明

Solutions are stable at 37°C for approximately 5 days. Aqueous stock solutions can be stored at 2-8°C for long term storage.

象形图

Health hazard
GHS08

警示用语：

Danger

危险声明

H360D

危险分类

Repr. 1B

储存分类代码

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 2

个人防护装备

Eyeshields, Gloves, type N95 (US)

法规信息

涉药品监管产品
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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000462292
0000462292
0000414758
0000414758
0000409191

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