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K1388

KT5823

Name: KT5823
Brand: SIGMA

≥85% (HPLC), lyophilized powder

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关于此项目

经验公式（希尔记法）:

C₂₉H₂₅N₃O₅

化学文摘社编号:

126643-37-6

分子量:

495.53

UNSPSC Code:

12352200

PubChem Substance ID:

24896206

NACRES:

NA.77

MDL number:

MFCD09878278

Assay:

≥85% (HPLC)

Form:

lyophilized powder

Quality level:

100

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产品名称

KT 5823, ≥85% (HPLC), lyophilized powder

Quality Level

100

assay

≥85% (HPLC)

form

lyophilized powder

color

white

solubility

ethyl acetate: 5 mg/mL

storage temp.

2-8°C

SMILES string

COC(=O)[C@]1(CC2O[C@]1(C)n3c4ccccc4c5c6CN(C)C(=O)c6c7c8ccccc8n2c7c35)OC

InChI

1S/C29H25N3O5/c1-28-29(36-4,27(34)35-3)13-20(37-28)31-18-11-7-5-9-15(18)22-23-17(14-30(2)26(23)33)21-16-10-6-8-12-19(16)32(28)25(21)24(22)31/h5-12,20H,13-14H2,1-4H3/t20-,28+,29+/m1/s1

InChI key

QTYMDECKVKSGSM-YMUMJAELSA-N

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General description

KT5823是一种蛋白激酶抑制剂。它可抑制鸟苷一磷酸（GMP）依赖性蛋白激酶活性（cGK）。它是一种星形孢菌素化合物，可促进促甲状腺激素并调节Na⁺/I⁻同向转运体(NIS)的表达。

Application

KT 5823已被用作皮质培养物、皮质神经元和小鼠脑毛细血管内皮细胞中环磷酸鸟苷（cGMP）依赖性蛋白激酶（PKG）抑制剂。

Biochem/physiol Actions

PKG的选择性抑制剂。

Features and Benefits

《受体分类和信号转导》手册的PKA & PKG页有该化合物的介绍。想要浏览手册的其他页面，请单击此处。

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Atrial Natriuretic Peptide Promotes Neurite Outgrowth and Survival of Cochlear Spiral Ganglion Neurons in vitro Through NPR-A/cGMP/PKG Signaling.

Fei Sun et al.

Frontiers in cell and developmental biology, 9, 681421-681421 (2021-07-17)

Sensorineural hearing loss (SNHL) is a dominant public health issue affecting millions of people around the globe, which is correlated with the irreversible deterioration of the hair cells and spiral ganglion neurons (SGNs) within the cochlea. Strategies using bioactive molecules

Essential role of nitric oxide in acute ischemic preconditioning: S-nitros(yl)ation versus sGC/cGMP/PKG signaling?

Junhui Sun et al.

Free radical biology & medicine, 54, 105-112 (2012-09-20)

Nitric oxide (NO) plays an important role in acute ischemic preconditioning (IPC). In addition to activating soluble guanylyl cyclase (sGC)/cyclic guanosine monophosphate (cGMP)/protein kinase G (PKG) signaling pathways, NO-mediated protein S-nitros(yl)ation (SNO) has been recently shown to play an essential

PIP2 depletion promotes TRPV4 channel activity in mouse brain capillary endothelial cells.

Harraz OF, et al.

eLife, 7(6), e38689-e38689 (2018)

Kaurenoic acid from Sphagneticola trilobata Inhibits Inflammatory Pain: effect on cytokine production and activation of the NO-cyclic GMP-protein kinase G-ATP-sensitive potassium channel signaling pathway.

Sandra S Mizokami et al.

Journal of natural products, 75(5), 896-904 (2012-05-12)

Kaurenoic acid [ent-kaur-16-en-19-oic acid (1)] is a diterpene present in several plants including Sphagneticola trilobata. The only documented evidence for its antinociceptive effect is that it inhibits the writhing response induced by acetic acid in mice. Therefore, the analgesic effect

Nitric oxide and guanylate cyclase signalling are differentially involved in gonadotrophin (LH) release responses to two endogenous GnRHs from goldfish pituitary cells.

A N Meints et al.

Journal of neuroendocrinology, 24(8), 1166-1181 (2012-04-11)

Nitric oxide synthase (NOS) immunoreactivity is present in goldfish gonadotrophs. The present study investigated whether two native goldfish gonadotrophin-releasing hormones (GnRHs), salmon (s)GnRH and chicken (c)GnRH-II, use NOS/nitric oxide (NO) and soluble guanylate cyclase (sGC)/cyclic (c)GMP/protein kinase G (PKG) signalling

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全球贸易项目编号

货号	GTIN
K1388-100UG	04061833867976

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