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K1514

Kurtoxin

Name: Kurtoxin
Brand: SIGMA

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关于此项目

经验公式（希尔记法）:

C₃₂₄H₄₇₈N₉₄O₉₀S₈

分子量:

7386.36

UNSPSC Code:

12352202

NACRES:

NA.32

MDL number:

MFCD04119124

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属性

form

solid

Quality Segment

200

shipped in

dry ice

storage temp.

−20°C

Gene Information

human ... CACNA1G(8913), CACNA1H(8912), CACNA1I(8911)
mouse ... CACNA1G(12291), CACNA1H(58226), CACNA1I(239556)
rat ... CACNA1G(29717), CACNA1H(114862), CACNA1I(56827)

说明

General description

Kurtoxin is hydrophobic in nature and shares sequence identity with α-scorpion and has cysteine-stabilized α-helix and β-sheet (CSαβ) motif. It interacts with N-type, and P-type calcium (Ca²⁺) channels as well.

Application

Kurtoxin has been used as a blocker of T-type and R-Type voltage-gated calcium channels (VGGCs) in hippocampal neurons.

Biochem/physiol Actions

Kurtoxin is isolated from the venom of the South African scorpion Parabuthus transvaalicus. It associates with voltage-gated sodium channels and delays their inactivation.

T-type Ca²⁺ channel blocker; Scorpion toxin

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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