form
solid
Quality Segment
shipped in
dry ice
storage temp.
−20°C
Gene Information
human ... CACNA1G(8913), CACNA1H(8912), CACNA1I(8911)
mouse ... CACNA1G(12291), CACNA1H(58226), CACNA1I(239556)
rat ... CACNA1G(29717), CACNA1H(114862), CACNA1I(56827)
General description
Kurtoxin is hydrophobic in nature and shares sequence identity with α-scorpion and has cysteine-stabilized α-helix and β-sheet (CSαβ) motif. It interacts with N-type, and P-type calcium (Ca2+) channels as well.
Application
Kurtoxin has been used as a blocker of T-type and R-Type voltage-gated calcium channels (VGGCs) in hippocampal neurons.
Biochem/physiol Actions
Kurtoxin is isolated from the venom of the South African scorpion Parabuthus transvaalicus. It associates with voltage-gated sodium channels and delays their inactivation.
T-type Ca2+ channel blocker; Scorpion toxin
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)