Merck
CN

K1750

Sigma-Aldrich

α-酮戊二酸

≥98.5% (NaOH, titration)

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别名:
2-氧代戊二酸, 2-氧化戊二酸
线性分子式:
HOOCCH2CH2COCOOH
CAS号:
分子量:
146.10
Beilstein:
1705689
EC 号:
MDL编号:
PubChem化学物质编号:
NACRES:
NA.32

质量水平

检测方案

≥98.5% (NaOH, titration)

形式

powder

溶解性

water: 100 mg/mL, clear to slightly hazy, colorless to faintly yellow

储存温度

2-8°C

SMILES字符串

OC(=O)CCC(=O)C(O)=O

InChI

1S/C5H6O5/c6-3(5(9)10)1-2-4(7)8/h1-2H2,(H,7,8)(H,9,10)

InChI key

KPGXRSRHYNQIFN-UHFFFAOYSA-N

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一般描述

αα-酮戊二酸(α-KG)在三羧酸循环中产生。

应用

αα-酮戊二酸(α-KG)已用于:
  • 研究其在体外发酵系统中对猪粪菌群的影响
  • 研究其对CD8+ T细胞的影响
  • 在谷氨酸-草酰乙酸转氨酶(GOT)线粒体裂解物检测中作为底物

生化/生理作用

αα-酮戊二酸(α-KG)广泛应用于动物饲料、食品、制药和精细化工行业。

象形图

Corrosion

警示用语:

Danger

危险声明

预防措施声明

危险分类

Eye Dam. 1

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

dust mask type N95 (US), Eyeshields, Gloves


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Long Liu et al.
Journal of biotechnology, 164(1), 97-104 (2013-01-22)
Currently, α-ketoglutaric acid (α-KG) is industrially produced by multi-step chemical synthesis, which can cause heavy environmental pollution. Here we reported a simple one-step approach for the production of α-KG by transforming l-glutamic acid with an engineered l-amino acid deaminase (l-AAD)
G Biagi et al.
Journal of animal science, 85(5), 1184-1191 (2007-02-14)
Adding organic acids to piglet diets is known to be helpful in overcoming postweaning syndrome, and butyric acid is known to be the main energy source for the epithelial cells of the large intestine and the terminal ileum. This study
J Kitaura et al.
European journal of pediatrics, 158(5), 410-413 (1999-05-20)
Two cases of hyperinsulinaemic hypoglycaemia associated with persistent hyperammonaemia in unrelated infants of 7 days and 4 months of age are reported. Blood ammonia levels were 100-300 micromol/l (normal values <40 micromol/l). The hyperammonaemia was asymptomatic and not associated with
F Rocchiccioli et al.
Biomedical mass spectrometry, 11(1), 24-28 (1984-01-01)
Quantification of 2-ketoglutaric acid in plasma and cerebrospinal fluid as its O-trimethylsilyl++-quinoxalinol derivative by gas chromatography chemical ionization mass spectrometry is described with benzoylformic acid as internal standard. This technique, with ammonia as reactant gas, only detects the protonated molecular
Victoria I Bunik et al.
International journal of molecular sciences, 21(11) (2020-05-30)
Genetic up-regulation of mitochondrial 2-oxoglutarate dehydrogenase is known to increase reactive oxygen species, being detrimental for cancer cells. Thiamine diphosphate (ThDP, cocarboxylase) is an essential activator of the enzyme and inhibits p53-DNA binding in cancer cells. We hypothesize that the

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