K1757
角质细胞生长因子 人
≥95% (SDS-PAGE and HPLC), recombinant, expressed in E. coli, powder, suitable for cell culture
别名:
hFGF-7, hKGF, FGF-7, KGF
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关于此项目
Biological source:
human
Recombinant:
expressed in E. coli
Assay:
≥95% (SDS-PAGE and HPLC)
Form:
powder
Mol wt:
18.9 kDa
Impurities:
1 EU/μg
产品名称
角质细胞生长因子 人, KGF, recombinant, expressed in E. coli, powder, suitable for cell culture
biological source
human
recombinant
expressed in E. coli
assay
≥95% (SDS-PAGE and HPLC)
form
powder
potency
0.1-15 ng/mL ED50/EC50
quality
endotoxin tested
mol wt
18.9 kDa
packaging
pkg of 10 and 50 μg
technique(s)
cell culture | mammalian: suitable
impurities
1 EU/μg
UniProt accession no.
storage temp.
−20°C
Quality Level
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General description
角质形成细胞生长因子（KGF）是一种18.9 kDa的生长因子，含有163个氨基酸，属于成纤维生长因子家族。它包含一段分泌信号序列，并与FGF-Basic具有39%的同源性。它在多种基质成纤维细胞系、间充质细胞中表达，但在正常胶质细胞和上皮细胞系中并不表达。
Application
人类角质形成细胞生长因子已被用于：
- 作为上皮生长培养基的一种组分
- 作为抗原的阳性对照用于测定抗体活性
- 分析KGF在减少心包粘连中与热灭菌羧甲基壳聚糖（NOCCts）相关的作用
Biochem/physiol Actions
角质形成细胞生长因子（KGF）可刺激角质形成细胞和其他上皮层中细胞的增殖和分化。它会诱导微血管内皮的细胞趋化以及大鼠角膜的新生血管形成。它可刺激正在发生增殖和迁移的基底细胞进行透明质酸合成。KGF有助于细胞在应激条件下的存活。KGF在受损和发生炎症的上皮细胞中具有高表达，从而促进伤口愈合。
Physical form
从含有0.5 mg牛血清白蛋白并经0.2 μm滤膜过滤的磷酸盐缓冲盐水中冻干。
Analysis Note
使用 4MBr-5 细胞进行细胞增殖试验来测定。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
法规信息
新产品
此项目有
Synergism between keratinocyte growth factor and carboxymethyl chitosan reduces pericardial adhesions
Lopes JB, et al.
The Annals of Thoracic Surgery, 90(2), 566-572 (2010)
Stimulation of in vivo angiogenesis by in situ crosslinked, dual growth factor-loaded, glycosaminoglycan hydrogels
Elia R, et al.
Biomaterials, 31(17), 4630-4638 (2010)
Keratinocyte growth factor (KGF) is required for postnatal thymic regeneration
Alpdogan O, et al.
Blood, 107(6), 2453-2460 (2006)
Characteristics of MIC-1 antlerogenic stem cells and their effect on hair growth in rabbits.
Cegielski M, et al.
In Vivo, 27(1), 97-106 (2013)
P Gillis et al.
Journal of cell science, 112 ( Pt 12), 2049-2057 (1999-05-26)
Keratinocyte growth factor (KGF), also called fibroblast growth factor-7, is widely known as a paracrine growth and differentiation factor that is produced by mesenchymal cells and has been thought to act specifically on epithelial cells. Here it is shown to
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