K1757
角质细胞生长因子 人
≥95% (SDS-PAGE and HPLC), recombinant, expressed in E. coli, powder, suitable for cell culture
别名:
hFGF-7, hKGF, FGF-7, KGF
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关于此项目
Biological source:
human
Recombinant:
expressed in E. coli
Assay:
≥95% (SDS-PAGE and HPLC)
Form:
powder
Mol wt:
18.9 kDa
Impurities:
1 EU/μg
产品名称
角质细胞生长因子 人, KGF, recombinant, expressed in E. coli, powder, suitable for cell culture
biological source
human
recombinant
expressed in E. coli
assay
≥95% (SDS-PAGE and HPLC)
form
powder
potency
0.1-15 ng/mL ED50/EC50
quality
endotoxin tested
mol wt
18.9 kDa
packaging
pkg of 10 and 50 μg
technique(s)
cell culture | mammalian: suitable
impurities
1 EU/μg
UniProt accession no.
storage temp.
−20°C
Quality Level
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General description
角质形成细胞生长因子（KGF）是一种18.9 kDa的生长因子，含有163个氨基酸，属于成纤维生长因子家族。它包含一段分泌信号序列，并与FGF-Basic具有39%的同源性。它在多种基质成纤维细胞系、间充质细胞中表达，但在正常胶质细胞和上皮细胞系中并不表达。
Application
人类角质形成细胞生长因子已被用于：
- 作为上皮生长培养基的一种组分
- 作为抗原的阳性对照用于测定抗体活性
- 分析KGF在减少心包粘连中与热灭菌羧甲基壳聚糖（NOCCts）相关的作用
Biochem/physiol Actions
角质形成细胞生长因子（KGF）可刺激角质形成细胞和其他上皮层中细胞的增殖和分化。它会诱导微血管内皮的细胞趋化以及大鼠角膜的新生血管形成。它可刺激正在发生增殖和迁移的基底细胞进行透明质酸合成。KGF有助于细胞在应激条件下的存活。KGF在受损和发生炎症的上皮细胞中具有高表达，从而促进伤口愈合。
Physical form
从含有0.5 mg牛血清白蛋白并经0.2 μm滤膜过滤的磷酸盐缓冲盐水中冻干。
Analysis Note
使用 4MBr-5 细胞进行细胞增殖试验来测定。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
法规信息
新产品
此项目有
Stimulation of in vivo angiogenesis by in situ crosslinked, dual growth factor-loaded, glycosaminoglycan hydrogels
Elia R, et al.
Biomaterials, 31(17), 4630-4638 (2010)
Synergism between keratinocyte growth factor and carboxymethyl chitosan reduces pericardial adhesions
Lopes JB, et al.
The Annals of Thoracic Surgery, 90(2), 566-572 (2010)
Keratinocyte growth factor (KGF) is required for postnatal thymic regeneration
Alpdogan O, et al.
Blood, 107(6), 2453-2460 (2006)
Characteristics of MIC-1 antlerogenic stem cells and their effect on hair growth in rabbits.
Cegielski M, et al.
In Vivo, 27(1), 97-106 (2013)
P Gillis et al.
Journal of cell science, 112 ( Pt 12), 2049-2057 (1999-05-26)
Keratinocyte growth factor (KGF), also called fibroblast growth factor-7, is widely known as a paracrine growth and differentiation factor that is produced by mesenchymal cells and has been thought to act specifically on epithelial cells. Here it is shown to
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