K1884
S-(+)-Ketamine hydrochloride
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关于此项目
经验公式（希尔记法）:
C13H16ClNO · HCl
CAS Number:
分子量:
274.19
MDL编号:
UNSPSC代码:
12352116
PubChem化学物质编号:
NACRES:
NA.77
表单
powder
质量水平
药品控制
USDEA Schedule III; stupéfiant (France); regulated under CDSA - not available from Sigma-Aldrich Canada; psicótropo (Spain)
储存温度
2-8°C
SMILES字符串
Cl.CN[C@@]1(CCCCC1=O)c2ccccc2Cl
InChI
1S/C13H16ClNO.ClH/c1-15-13(9-5-4-8-12(13)16)10-6-2-3-7-11(10)14;/h2-3,6-7,15H,4-5,8-9H2,1H3;1H/t13-;/m0./s1
InChI key
VCMGMSHEPQENPE-ZOWNYOTGSA-N
基因信息
human ... GRIN1(2902), GRIN2A(2903), GRIN2B(2904), GRIN2C(2905), GRIN2D(2906), GRIN3A(116443), GRIN3B(116444)
生化/生理作用
Selective NMDA glutamate receptor antagonist.
警示用语：
Warning
危险分类
Acute Tox. 4 Oral - Carc. 2 - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
靶器官
Respiratory system
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type P3 (EN 143) respirator cartridges
法规信息
新产品
Martin Chopra et al.
PloS one, 8(9), e75737-e75737 (2013-10-08)
Multiple activities are ascribed to the cytokine tumor necrosis factor (TNF) in health and disease. In particular, TNF was shown to affect carcinogenesis in multiple ways. This cytokine acts via the activation of two cell surface receptors, TNFR1, which is
Martin Chopra et al.
PloS one, 8(12), e81320-e81320 (2013-12-19)
To promote cancer research and to develop innovative therapies, refined pre-clinical mouse tumor models that mimic the actual disease in humans are of dire need. A number of neoplasms along the B cell lineage are commonly initiated by a translocation
M Nishimura et al.
Neuroscience letters, 274(2), 131-134 (1999-12-20)
Ketamine is usually administered as a racemate, which is composed of the two isomers, S(+)-and R(-)-ketamine. Recently, we have shown that racemic ketamine at clinical relevant concentrations specifically inhibits the transporter proteins for norepinephrine, dopamine and serotonin heterologously expressed in
Adam L Halberstadt et al.
Psychopharmacology, 233(7), 1215-1225 (2016-01-14)
Methoxetamine (MXE) is a ketamine analog sold online that has been subject to widespread abuse for its dissociative and hallucinogenic effects. Previous studies have shown that MXE has high affinity for the phencyclidine (PCP) binding site located within the channel
T Kawasaki et al.
Anesthesia and analgesia, 89(3), 665-669 (1999-09-04)
The production of proinflammatory cytokines, such as tumor necrosis factor (TNF) a, interleukin (IL)-6, and IL-8, increases in patients with sepsis; marked production causes organ failure and septic shock. We previously reported that ketamine suppressed lipopolysaccharide (LPS)-induced TNF-alpha production in
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