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Merck
CN

K2010

α-酮戊二酸钠 钠盐

BioUltra

别名:

2-氧代戊二酸 单钠盐, 2-氧化戊二酸 单钠盐, 2-酮戊二酸钠 一元

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关于此项目

线性分子式:
HOOCCH2CH2COCOONa
化学文摘社编号:
22202-68-2
分子量:
168.08
UNSPSC Code:
12352204
NACRES:
NA.32
PubChem Substance ID:
24896216
EC Number:
244-836-6
Beilstein/REAXYS Number:
4597521
MDL number:
MFCD00064196

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产品名称

α-酮戊二酸钠 钠盐, BioUltra

InChI key

MOTOGHHLNTXPTI-UHFFFAOYSA-M

InChI

1S/C5H6O5.Na/c6-3(5(9)10)1-2-4(7)8;/h1-2H2,(H,7,8)(H,9,10);/q;+1/p-1

SMILES string

[Na+].OC(=O)CCC(=O)C([O-])=O

product line

BioUltra

assay

≥98% (perchloric acid titration)

form

powder

impurities

≤0.0005% Phosphorus (P)
≤0.1% Insoluble matter

solubility

H2O: 0.5 M, clear, colorless

anion traces

chloride (Cl-): ≤0.05%
sulfate (SO42-): ≤0.05%

cation traces

Al: ≤0.0005%
Ca: ≤0.001%
Cu: ≤0.0005%
Fe: ≤0.0005%
K: ≤0.005%
Mg: ≤0.0005%
NH4+: ≤0.05%
Pb: ≤0.001%
Zn: ≤0.0005%

storage temp.

2-8°C

Quality Level

200

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相关类别

Application

α-酮戊二酸钠盐已用于人犬尿氨酸氨基转移酶II（KAT-II）的抑菌谱测定。

Biochem/physiol Actions

α-酮戊二酸是L-谷氨酸的前体。
α-酮戊二酸是TCA循环中的关键中间体。它还可与细胞内释放的氮结合，从而在防止氮超载方面发挥重要作用。

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000478756
0000478756
0000468247
0000468247
0000369172

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Structure-based design of irreversible human KAT II inhibitors: Discovery of new potency-enhancing interactions
Tuttle JB, et al.
ACS Medicinal Chemistry Letters, 4(1), 37-40 (2012)
Amino Acids in Therapy: A Guide to the Therapeutic Application of Protein Constituents, 34-34 (1985)
Piotr Dobrowolski et al.
Nutrition (Burbank, Los Angeles County, Calif.), 29(3), 556-561 (2012-12-12)
Proton-pump inhibitors, such as omeprazole, are widely used in the prevention and treatment of gastroesophageal diseases. However, an association between proton-pump inhibitors and the increased risk of bone fractures has been observed, especially in patients treated for extended periods. Conversely
Michael E Jung et al.
The Journal of organic chemistry, 77(23), 11002-11005 (2012-11-21)
Oxidative cleavage of cycloalkene-1-carboxylates, made from the corresponding carboxylic acids, and subsequent oxidation of the resulting ketoaldehyde afforded the important 1-monoesters of 2-ketoalkanedioic acids. Thus ozonolysis of octyl cyclobutene-1-carboxylate followed by sodium chlorite oxidation afforded the 1-monooctyl 2-ketoglutarate. This is
Vivian R Moure et al.
Journal of bacteriology, 195(2), 279-286 (2012-11-13)
Fe protein (dinitrogenase reductase) activity is reversibly inactivated by dinitrogenase reductase ADP-ribosyltransferase (DraT) in response to an increase in the ammonium concentration or a decrease in cellular energy in Azospirillum brasilense, Rhodospirillum rubrum, and Rhodobacter capsulatus. The ADP-ribosyl is removed
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