K2015
K-252a
From Nonomuraea longicatena, >98%, tyrosine kinase receptor inhibitor, solution
别名:
SF 2370
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关于此项目
经验公式（希尔记法）:
C27H21N3O5
CAS Number:
分子量:
467.47
EC 号:
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.77
Product Name
K-252a, Ready Made Solution, from Nonomuraea longicatena, >98%
生物来源
Nonomuraea longicatena
质量水平
方案
>98%
表单
solution
运输
dry ice
储存温度
−20°C
SMILES字符串
[H][C@]12C[C@](O)(C(=O)OC)[C@](C)(O1)n3c4ccccc4c5c6CNC(=O)c6c7c8ccccc8n2c7c35
InChI
1S/C27H21N3O5/c1-26-27(33,25(32)34-2)11-18(35-26)29-16-9-5-3-7-13(16)20-21-15(12-28-24(21)31)19-14-8-4-6-10-17(14)30(26)23(19)22(20)29/h3-10,18,33H,11-12H2,1-2H3,(H,28,31)/t18-,26+,27+/m1/s1
InChI key
KOZFSFOOLUUIGY-SOLYNIJKSA-N
基因信息
human ... NTRK1(4914)
rat ... Prkca(24680)
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相关类别
储存分类代码
10 - Combustible liquids
WGK
WGK 1
闪点(°F)
188.6 °F - closed cup
闪点(°C)
87 °C - closed cup
个人防护装备
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Z Pawlowska et al.
Journal of neurochemistry, 60(2), 678-686 (1993-02-01)
The phosphorylation of surface proteins by ecto-protein kinase has been proposed to play a role in mechanisms underlying neuronal differentiation and their responsiveness to nerve growth factor (NGF). PC12 clones represent an optimal model for investigating the mode of action
M A Glicksman et al.
Journal of neurochemistry, 64(4), 1502-1512 (1995-04-01)
The organic molecule K-252a promoted cell survival, neurite outgrowth, and increased choline acetyltransferase (ChAT) activity in rat embryonic striatal and basal forebrain cultures in a concentration-dependent manner. A two- to threefold increase in survival was observed at 75 nM K-252a
L S Chin et al.
Cancer investigation, 17(6), 391-395 (1999-08-06)
The indole carbazole K252a has been shown in previous studies to inhibit the platelet-derived growth factor signal transduction pathway in gliomas. Because K252a has nonspecific effects on protein kinase function, we studied its effect on cyclin-dependent kinases (CDK) and cell
Winston, J.H., et al.
Pain, 4, 329-337 (2003)
Haridas B Rode et al.
Bioorganic & medicinal chemistry, 19(1), 429-439 (2010-12-07)
Here we present the synthesis and biological activity of a series of 7-substituted-1-(3-bromophenylamino)isoquinoline-4-carbonitriles as inhibitors of myosin light chain kinase (MLCK) and the epidermal growth factor receptor kinase (EGFR). The inhibitory effect of these molecules was found to be dependent
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