K2380
D-尿嘧啶
别名:
β-蒽基-D-丙氨酸, D-2-氨基-4-(2-氨基苯)-4-氧代丁酸
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关于此项目
经验公式（希尔记法）:
C10H12N2O3
化学文摘社编号:
分子量:
208.21
NACRES:
NA.26
PubChem Substance ID:
UNSPSC Code:
12352202
MDL number:
InChI
1S/C10H12N2O3/c11-7-4-2-1-3-6(7)9(13)5-8(12)10(14)15/h1-4,8H,5,11-12H2,(H,14,15)/t8-/m1/s1
SMILES string
N[C@H](CC(=O)c1ccccc1N)C(O)=O
InChI key
YGPSJZOEDVAXAB-MRVPVSSYSA-N
assay
≥98% (TLC)
form
powder
technique(s)
ligand binding assay: suitable
color
faint yellow to yellow
application(s)
cell analysis
Biochem/physiol Actions
D-犬尿素可以与L-犬尿素一起使用，以评估犬尿素代谢酶的特异性和动力学。D-犬尿素可用于研究G蛋白偶联受体GPR109B的选择性和活性。D-犬尿素可在D-氨基酸氧化酶的荧光分析中用作底物。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Sumiko Iwasa et al.
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, 131(7), 1111-1116 (2011-07-02)
A facile fluorometric assay using D-kynurenine as a substrate was utilized for evaluating the inhibition of D-amino acid oxidase (DAAO), which is one of the products of a susceptibility gene for schizophrenia, by commercial antipsychotic drugs, namely, chlorpromazine (CPZ), carbamazepine
Masato Hoshi et al.
Toxicology, 438, 152458-152458 (2020-04-15)
Kynurenine (Kyn) plays an important role as an immune check-point molecule and regulates various immune responses through its aryl hydrocarbon receptor (Ahr). Kyn is synthesized by indoleamine 2,3-dioxygenase (Ido) and tryptophan 2,3-dioxygenase (Tdo). Ido contributes approximately 90% of tryptophan catabolism.
Olger Huaman et al.
Research in veterinary science, 124, 212-222 (2019-03-30)
Little information is currently available on therapeutic features of bovine mesenchymal stem cells (MSCs), despite the development of large animal experimental models including cattle may open alternative strategies for investigating MSC physiology and eventual applications for regenerative therapy. The aim
Harold A Walsh et al.
European journal of biochemistry, 269(8), 2069-2074 (2002-05-03)
Recombinant human kynureninase (L-kynurenine hydrolase, EC 3.7.1.3) was purified to homogeneity (60-fold) from Spodoptera frugiperda (Sf9) cells infected with baculovirus containing the kynureninase gene. The purification protocol comprised ammonium sulfate precipitation and several chromatographic steps, including DEAE-Sepharose CL-6B, hydroxyapatite, strong
Kana Ishii et al.
Chirality, 22(10), 901-906 (2010-09-28)
An aqueous solution of enantiomerically pure tryptophan (Trp), namely, D-Trp or L-Trp (100 mg/kg), was administered intraperitoneally to male Sprague-Dawley rats. The time-course profiles of the rat plasma concentrations of D-kynurenine (KYN), L-KYN, and kynurenic acid (KYNA), which are metabolites
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