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K2380

D-尿嘧啶

Name: <SC>D</SC>-尿嘧啶
Brand: SIGMA

别名:

β-蒽基-D-丙氨酸, D-2-氨基-4-(2-氨基苯)-4-氧代丁酸

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关于此项目

经验公式（希尔记法）:

C₁₀H₁₂N₂O₃

化学文摘社编号:

13441-51-5

分子量:

208.21

NACRES:

NA.26

PubChem Substance ID:

24896220

UNSPSC Code:

12352202

MDL number:

MFCD00133224

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属性

assay

≥98% (TLC)

form

powder

technique(s)

ligand binding assay: suitable

color

faint yellow to yellow

application(s)

cell analysis

SMILES string

N[C@H](CC(=O)c1ccccc1N)C(O)=O

InChI

1S/C10H12N2O3/c11-7-4-2-1-3-6(7)9(13)5-8(12)10(14)15/h1-4,8H,5,11-12H2,(H,14,15)/t8-/m1/s1

InChI key

YGPSJZOEDVAXAB-MRVPVSSYSA-N

说明

Biochem/physiol Actions

D-犬尿素可以与L-犬尿素一起使用，以评估犬尿素代谢酶的特异性和动力学。D-犬尿素可用于研究G蛋白偶联受体GPR109B的选择性和活性。D-犬尿素可在D-氨基酸氧化酶的荧光分析中用作底物。

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Kynurenine produced by indoleamine 2,3-dioxygenase 2 exacerbates acute liver injury by carbon tetrachloride in mice.

Masato Hoshi et al.

Toxicology, 438, 152458-152458 (2020-04-15)

Kynurenine (Kyn) plays an important role as an immune check-point molecule and regulates various immune responses through its aryl hydrocarbon receptor (Ahr). Kyn is synthesized by indoleamine 2,3-dioxygenase (Ido) and tryptophan 2,3-dioxygenase (Tdo). Ido contributes approximately 90% of tryptophan catabolism.

Inhibition of D-amino acid oxidase activity by antipsychotic drugs evaluated by a fluorometric assay using D-kynurenine as substrate.

Sumiko Iwasa et al.

Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, 131(7), 1111-1116 (2011-07-02)

A facile fluorometric assay using D-kynurenine as a substrate was utilized for evaluating the inhibition of D-amino acid oxidase (DAAO), which is one of the products of a susceptibility gene for schizophrenia, by commercial antipsychotic drugs, namely, chlorpromazine (CPZ), carbamazepine

Determination of Kynurenine Enantiomers by Alpha-Cyclodextrin, Cationic-βeta-Cyclodextrin and Their Synergy Complemented with Stacking Enrichment in Capillary Electrophoresis.

Aysha Sarfraz Rizvi et al.

Journal of chromatography. A, 1622, 461128-461128 (2020-04-26)

We present high resolution fast, cost-effective and sensitive Capillary zone electrophoresis (CZE) methods for determination of enantiomeric compounds of Kynurenine pathway, i.e. D, L-Kynurenine (KYN), in human serum and urine samples by cationic-β-CD and its synergistic dual chiral selector system

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全球贸易项目编号

货号	GTIN
K2380-25MG	04061832416687