K2380
D-尿嘧啶
别名:
β-蒽基-D-丙氨酸, D-2-氨基-4-(2-氨基苯)-4-氧代丁酸
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关于此项目
经验公式（希尔记法）:
C10H12N2O3
化学文摘社编号:
分子量:
208.21
MDL编号:
UNSPSC代码:
12352202
PubChem化学物质编号:
NACRES:
NA.26
方案
≥98% (TLC)
表单
powder
技术
ligand binding assay: suitable
颜色
faint yellow to yellow
应用
cell analysis
SMILES字符串
N[C@H](CC(=O)c1ccccc1N)C(O)=O
InChI
1S/C10H12N2O3/c11-7-4-2-1-3-6(7)9(13)5-8(12)10(14)15/h1-4,8H,5,11-12H2,(H,14,15)/t8-/m1/s1
InChI key
YGPSJZOEDVAXAB-MRVPVSSYSA-N
生化/生理作用
D-犬尿素可以与L-犬尿素一起使用，以评估犬尿素代谢酶的特异性和动力学。D-犬尿素可用于研究G蛋白偶联受体GPR109B的选择性和活性。D-犬尿素可在D-氨基酸氧化酶的荧光分析中用作底物。
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
Masato Hoshi et al.
Toxicology, 438, 152458-152458 (2020-04-15)
Kynurenine (Kyn) plays an important role as an immune check-point molecule and regulates various immune responses through its aryl hydrocarbon receptor (Ahr). Kyn is synthesized by indoleamine 2,3-dioxygenase (Ido) and tryptophan 2,3-dioxygenase (Tdo). Ido contributes approximately 90% of tryptophan catabolism.
Olger Huaman et al.
Research in veterinary science, 124, 212-222 (2019-03-30)
Little information is currently available on therapeutic features of bovine mesenchymal stem cells (MSCs), despite the development of large animal experimental models including cattle may open alternative strategies for investigating MSC physiology and eventual applications for regenerative therapy. The aim
Sumiko Iwasa et al.
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, 131(7), 1111-1116 (2011-07-02)
A facile fluorometric assay using D-kynurenine as a substrate was utilized for evaluating the inhibition of D-amino acid oxidase (DAAO), which is one of the products of a susceptibility gene for schizophrenia, by commercial antipsychotic drugs, namely, chlorpromazine (CPZ), carbamazepine
Yoko Irukayama-Tomobe et al.
Proceedings of the National Academy of Sciences of the United States of America, 106(10), 3930-3934 (2009-02-25)
GPR109B (HM74) is a putative G protein-coupled receptor (GPCR) whose cognate ligands have yet to be characterized. GPR109B shows a high degree of sequence similarity to GPR109A, another GPCR that was identified as a high-affinity nicotinic acid (niacin) receptor. However
Kana Ishii et al.
Chirality, 22(10), 901-906 (2010-09-28)
An aqueous solution of enantiomerically pure tryptophan (Trp), namely, D-Trp or L-Trp (100 mg/kg), was administered intraperitoneally to male Sprague-Dawley rats. The time-course profiles of the rat plasma concentrations of D-kynurenine (KYN), L-KYN, and kynurenic acid (KYNA), which are metabolites
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