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经验公式(希尔记法):
C19H19NOS · C4H4O4
化学文摘社编号:
分子量:
425.50
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
EC Number:
252-100-0
MDL number:
产品名称
酮替芬 富马酸盐,
InChI key
YNQQEYBLVYAWNX-WLHGVMLRSA-N
InChI
1S/C19H19NOS.C4H4O4/c1-20-9-6-13(7-10-20)18-15-5-3-2-4-14(15)12-17(21)19-16(18)8-11-22-19;5-3(6)1-2-4(7)8/h2-5,8,11H,6-7,9-10,12H2,1H3;1-2H,(H,5,6)(H,7,8)/b;2-1+
SMILES string
OC(=O)\C=C\C(O)=O.CN1CCC(\CC1)=C2/c3ccccc3CC(=O)c4sccc24
form
powder
originator
Novartis
Quality Level
Gene Information
human ... HRH1(3269), PDE7B(27115)
相关类别
General description
富马酸酮替芬盐是一种抗组胺药。
Application
富马酸酮替芬盐已被用于:肥大细胞产物拮抗作用,作为 β-氨基己糖苷酶释放测试的阳性对照,作为肥大细胞稳定剂添加到饮用水中用于治疗怀孕母兽
Biochem/physiol Actions
H1 组胺受体拮抗剂。
富马酸酮替芬通过阻断组胺H1受体而在阻止组胺的释放中起关键作用。它会干扰肥大细胞释放组胺、血清素和其他炎症介质。它具有抗过敏活性、消炎作用(包括使肥大细胞稳定)。它已被广泛用于眼部过敏性结膜炎。
ppe
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Eye Irrit. 2
存储类别
11 - Combustible Solids
wgk
WGK 3
Jeffrey KA
Side Effects of Drugs Annual (2005)
X Lin et al.
Life sciences, 63(2), 145-153 (1998-07-23)
The Differential Display technique has been used to identify differences in mRNA expression in adipose tissue after the introduction of a high fat diet to two strains of rat (OM and S5B/PI) that differ in their susceptibility to develop obesity
Richard T Eastman et al.
Antimicrobial agents and chemotherapy, 57(1), 425-435 (2012-11-07)
Malaria is a deadly infectious disease in many tropical and subtropical countries. Previous efforts to eradicate malaria have failed, largely due to the emergence of drug-resistant parasites, insecticide-resistant mosquitoes and, in particular, the lack of drugs or vaccines to block
William L
Anabolics (2011)
Michael J Monument et al.
Inflammation research : official journal of the European Histamine Research Society ... [et al.], 61(4), 285-292 (2011-12-17)
Using a rabbit model of post-traumatic joint contractures, we investigated whether treatment with a mast cell stabilizer after joint injury would lessen the molecular manifestations of joint capsule fibrosis. Surgical joint injury was used to create stable post-traumatic contractures of
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