K3125
曲酸
≥98.5% (HPLC), powder, tyrosinase inhibitor
别名:
2-羟甲基-5-羟基-γ-吡喃酮, 5-羟基-2-羟甲基-4H-4-吡喃酮
产品名称
曲酸,
方案
≥98.5% (HPLC)
质量水平
表单
powder
mp
152-155 °C (lit.)
SMILES字符串
OCC1=CC(=O)C(O)=CO1
InChI
1S/C6H6O4/c7-2-4-1-5(8)6(9)3-10-4/h1,3,7,9H,2H2
InChI key
BEJNERDRQOWKJM-UHFFFAOYSA-N
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应用
曲酸已被用于：
- 作为豚鼠色素性远视 (PH) 中酪氨酸酶的抑制剂
- 作为引用抑制剂标准用于筛选酪氨酸酶抑制
- 作为 B16F10 黑色素瘤细胞中酪氨酸酶抑制的阳性对照
生化/生理作用
曲酸来源于曲霉菌属、醋酸杆菌属和青霉属等真菌。它通过抑制酪氨酸酶而使黑色素合成停止。用于皮肤美白化妆品的制备。然而，曲酸在化妆品中的使用很少，因为其在长期储存期间的不稳定性和细胞毒性导致皮肤刺激。它是一种抗氧化剂，对锰和锌的螯合起辐射保护作用。
酪氨酸酶抑制剂。
储存分类代码
11 - Combustible Solids
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
Effects of the Tyrosinase-Dependent Dopaminergic System on Refractive Error Development in Guinea Pigs
Jiang L, et al.
Investigative Ophthalmology & Visual Science, 59(11), 4631-4638 (2018)
Ka-Heng Lee et al.
European journal of medicinal chemistry, 44(8), 3195-3200 (2009-04-11)
A series of 46 curcumin related diarylpentanoid analogues were synthesized and evaluated for their anti-inflammatory, antioxidant and anti-tyrosinase activities. Among these compounds 2, 13 and 33 exhibited potent NO inhibitory effect on IFN-gamma/LPS-activated RAW 264.7 cells as compared to L-NAME
Wei Yi et al.
European journal of medicinal chemistry, 46(9), 4330-4335 (2011-07-23)
Melanin play a major role in human skin protection and their biosynthesis is vital. Due to their color, they contribute to the skin pigmentation. Tyrosinase is a key enzyme involved in the first stage of melanin biosynthesis, it catalyzes the
Xiao Hu et al.
Journal of natural products, 75(1), 82-87 (2011-12-15)
Two novel 2-arylbenzofuran dimers, morusyunnansins A and B (1 and 2), two new biflavonoids, morusyunnansins C and D (3 and 4), two new flavans, morusyunnansins E and F (5 and 6), and four known flavans (7-10) were isolated from the
Kojic acid and its manganese and zinc complexes as potential radioprotective agents
Emami S, et al.
Bioorganic & Medicinal Chemistry Letters, 17(1), 45-48 (2007)
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