K3513
Anti-KIF3A antibody produced in rabbit
IgG fraction of antiserum, buffered aqueous solution
别名:
Anti-FLA10, Anti-KLP-20
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关于此项目
Conjugate:
unconjugated
Clone:
polyclonal
Application:
ARR, IHC, WB
Citations:
16
biological source
rabbit
conjugate
unconjugated
antibody form
IgG fraction of antiserum
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
species reactivity
rat, mouse, human
packaging
antibody small pack of 25 μL
technique(s)
immunohistochemistry: suitable using suitable for IHC on rat brain perfused with 4% paraformaldehyde, microarray: suitable, western blot: 1:2,000 using rat brain homogenate and whole cell extract of rat pheochromocytoma PC12 cell line.
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... KIF3A(11127)
mouse ... Kif3a(16568)
rat ... Kif3a(84392)
General description
KIF3A/B is abundantly expressed in neuronal tissue and ubiquitously expressed in other tissues in lower amounts.
The gene KIF3A (kinesin family member 3A) is mapped to human chromosome 5q31.1. The gene encodes a subunit of heterotrimeric kinesin-2, which is a canonical plus-oriented anterograde IFT (intraflagellar transport) motor.
Immunogen
synthetic peptide corresponding to the C-terminus of mouse KIF3A (amino acids 682-701) conjugated to KLH.
Application
Anti-KIF3A antibody produced in rabbit has been used in immunohistochemistry and immunofluorescence.
Anti-KIF3A antibody produced in rabbit has been used in:
- immunoblotting
- immunohistochemical detection of kinesin family member 3A (KIF3A)
Biochem/physiol Actions
The gene KIF3A (kinesin family member 3A) encodes a motor subunit of kinesin-2, a protein that functions in the formation and mechanism of cilia. The chromosomal region to which the gene is mapped is linked to immune diseases, such as asthma.
The kinesin superfamily (KIFs) of proteins consists of a class of microtubule-dependent motors that plays a major role in many cellular and developmental functions, including organelle transport, mitosis, meiosis, and possibly long-range signaling in neurons. KIF3 plays a crucial role during development. KIF3A-/- and KIF3B-/- mice do not survive beyond mid-gestation. Embryos lacking KIF3A and KIF3B display randomization of left-right asymmetry and numerous morphological abnormalities. The KIF3A/B heterodimer exhibits a plus end-directed microtubule sliding activity.
Physical form
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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存储类别
10 - Combustible liquids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
低风险生物材料
常规特殊物品
此项目有
KIF3A/B: a heterodimeric kinesin superfamily protein that works as a microtubule plus end-directed motor for membrane organelle transport.
Yamazaki H, et al.
The Journal of Cell Biology, 130(6), 1387-1399 (1995)
Peixuan Xia et al.
Biomedical reports, 8(4), 343-349 (2018-03-16)
Kinesin Family Member 3A (KIF3A) was recognized as a key factor of ciliogenesis and transport system of primary cilia in normal cells. However, its possible function on cancer cells has yet to be identified. In the present study, microarray tissue
High expression of KIF3A is a potential new parameter for the diagnosis and prognosis of breast cancer
Xia P, et al.
Biomedical Reports, 8(4), 343-349 (2018)
Investigating primary cilia in cultured metanephric mesenchymal cells.
Chi L and Rosenblum N
Methods in Molecular Biology, 886, 157-163 (2012)
Left-Right Asymmetry and Kinesin Superfamily Protein KIF3A: New Insights in Determination of Laterality and Mesoderm Induction by kif3A
Takeda S, et al.
The Journal of cell biology, 145(4), 825-825 (1999)
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