K3644
K 858
≥98% (HPLC)
别名:
K858, N-(4-Acetyl-4,5-dihydro-5-methyl-5-phenyl-1,3,4-thiadia zol-2-yl)acetamide
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关于此项目
经验公式（希尔记法）:
C13H15N3O2S
化学文摘社编号:
分子量:
277.34
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352202
MDL number:
InChI
1S/C13H15N3O2S/c1-9(17)14-12-15-16(10(2)18)13(3,19-12)11-7-5-4-6-8-11/h4-8H,1-3H3,(H,14,15,17)
SMILES string
CC(=O)NC1=NN(C(C)=O)C(C)(S1)c2ccccc2
InChI key
JEFVYQYZCAVNTP-UHFFFAOYSA-N
assay
≥98% (HPLC)
form
powder
color
white to off-white
solubility
DMSO: ≥20 mg/mL
storage temp.
2-8°C
Quality Level
Biochem/physiol Actions
A thiadiazoline derivative reported as a selective ATP-uncompetitive mitotic kinesin Eg5 inhibitor.
Eg5 is a key protein involved in the formation of bipolar spindles. K858 is a selective ATP-uncompetitive mitotic kinesin Eg5 inhibitor. The compound induces mitotic arrest, caspase-3 activation and cell growth inhibition in HCT116 cells.
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral
存储类别
11 - Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
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