K4144
KB-R7943
≥98% (HPLC), powder
别名:
2- [4-[（4-硝基苯基）甲氧基]苯基]乙酯，甲磺酸酯（1：1）, 氨基甲硫基酸
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关于此项目
经验公式（希尔记法）:
C16H17N3O3S·CH3SO3H
化学文摘社编号:
分子量:
427.50
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
产品名称
KB-R7943, ≥98% (HPLC), powder
InChI key
WGIKEBHIKKWJLG-UHFFFAOYSA-N
SMILES string
CS(O)(=O)=O.NC(=N)SCCc1ccc(OCc2ccc(cc2)[N+]([O-])=O)cc1
InChI
1S/C16H17N3O3S.CH4O3S/c17-16(18)23-10-9-12-3-7-15(8-4-12)22-11-13-1-5-14(6-2-13)19(20)21;1-5(2,3)4/h1-8H,9-11H2,(H3,17,18);1H3,(H,2,3,4)
assay
≥98% (HPLC)
form
powder
color
off-white to tan
solubility
DMSO: >10 mg/mL
storage temp.
2-8°C
Quality Level
相关类别
Biochem/physiol Actions
KB-R7943 抑制反转的 Na（+）/Ca（2+）交换剂 NCX。
KB-R7943 抑制反转的 Na（+）/Ca（2+）交换剂 NCX。在心肌细胞中，Ca2+ 在收缩过程中从胞内存储中释放出来，在舒张过程中再被吸收回胞内。NCX 是防止 Ca2+ 超载的主要机制，因为钙离子跨质膜流入。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Pascaline Clerc et al.
PloS one, 7(4), e34465-e34465 (2012-04-13)
Mitochondrial dysfunction is a component of many neurodegenerative conditions. Measurement of oxygen consumption from intact neurons enables evaluation of mitochondrial bioenergetics under conditions that are more physiologically realistic compared to isolated mitochondria. However, mechanistic analysis of mitochondrial function in cells
Lorena Halty-deLeon et al.
Frontiers in cellular neuroscience, 12, 186-186 (2018-07-19)
CALX, the Na+/Ca2+ exchanger in Drosophila, is highly expressed in the outer dendrites of olfactory sensory neurons (OSNs) which are equipped with the odorant receptors (ORs). Insect OR/Orco dimers are nonselective cation channels that pass also calcium which leads to
Ignacio Ibáñez et al.
Neurochemistry international, 123, 125-132 (2018-03-27)
GLT-1 is the main glutamate transporter in the brain and its trafficking controls its availability at the cell surface, thereby shaping glutamatergic neurotransmission under physiological and pathological conditions. Extracellular glutamate is known to trigger ubiquitin-dependent GLT-1 internalization from the surface
Camille Loubiere et al.
Scientific reports, 7(1), 5040-5040 (2017-07-13)
Mitochondrial integrity is critical for the regulation of cellular energy and apoptosis. Metformin is an energy disruptor targeting complex I of the respiratory chain. We demonstrate that metformin induces endoplasmic reticulum (ER) stress, calcium release from the ER and subsequent
Reno C Reyes et al.
ASN neuro, 4(1) (2012-01-25)
Astroglial excitability operates through increases in Ca2+cyt (cytosolic Ca2+), which can lead to glutamatergic gliotransmission. In parallel fluctuations in astrocytic Na+cyt (cytosolic Na+) control metabolic neuronal-glial signalling, most notably through stimulation of lactate production, which on release from astrocytes can
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