K4144
KB-R7943
≥98% (HPLC), powder
别名:
2- [4-[（4-硝基苯基）甲氧基]苯基]乙酯，甲磺酸酯（1：1）, 氨基甲硫基酸
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关于此项目
经验公式（希尔记法）:
C16H17N3O3S·CH3SO3H
CAS Number:
分子量:
427.50
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.77
质量水平
方案
≥98% (HPLC)
表单
powder
颜色
off-white to tan
溶解性
DMSO: >10 mg/mL
储存温度
2-8°C
SMILES字符串
CS(O)(=O)=O.NC(=N)SCCc1ccc(OCc2ccc(cc2)[N+]([O-])=O)cc1
InChI
1S/C16H17N3O3S.CH4O3S/c17-16(18)23-10-9-12-3-7-15(8-4-12)22-11-13-1-5-14(6-2-13)19(20)21;1-5(2,3)4/h1-8H,9-11H2,(H3,17,18);1H3,(H,2,3,4)
InChI key
WGIKEBHIKKWJLG-UHFFFAOYSA-N
相关类别
生化/生理作用
KB-R7943 抑制反转的 Na（+）/Ca（2+）交换剂 NCX。
KB-R7943 抑制反转的 Na（+）/Ca（2+）交换剂 NCX。在心肌细胞中，Ca2+ 在收缩过程中从胞内存储中释放出来，在舒张过程中再被吸收回胞内。NCX 是防止 Ca2+ 超载的主要机制，因为钙离子跨质膜流入。
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Lorena Halty-deLeon et al.
Frontiers in cellular neuroscience, 12, 186-186 (2018-07-19)
CALX, the Na+/Ca2+ exchanger in Drosophila, is highly expressed in the outer dendrites of olfactory sensory neurons (OSNs) which are equipped with the odorant receptors (ORs). Insect OR/Orco dimers are nonselective cation channels that pass also calcium which leads to
Ignacio Ibáñez et al.
Neurochemistry international, 123, 125-132 (2018-03-27)
GLT-1 is the main glutamate transporter in the brain and its trafficking controls its availability at the cell surface, thereby shaping glutamatergic neurotransmission under physiological and pathological conditions. Extracellular glutamate is known to trigger ubiquitin-dependent GLT-1 internalization from the surface
Camille Loubiere et al.
Scientific reports, 7(1), 5040-5040 (2017-07-13)
Mitochondrial integrity is critical for the regulation of cellular energy and apoptosis. Metformin is an energy disruptor targeting complex I of the respiratory chain. We demonstrate that metformin induces endoplasmic reticulum (ER) stress, calcium release from the ER and subsequent
Sandra Mitrovic et al.
eLife, 2, e00658-e00658 (2013-06-07)
Mucin 5AC (MUC5AC) is secreted by goblet cells of the respiratory tract and, surprisingly, also expressed de novo in mucus secreting cancer lines. siRNA-mediated knockdown of 7343 human gene products in a human colonic cancer goblet cell line (HT29-18N2) revealed
Reno C Reyes et al.
ASN neuro, 4(1) (2012-01-25)
Astroglial excitability operates through increases in Ca2+cyt (cytosolic Ca2+), which can lead to glutamatergic gliotransmission. In parallel fluctuations in astrocytic Na+cyt (cytosolic Na+) control metabolic neuronal-glial signalling, most notably through stimulation of lactate production, which on release from astrocytes can
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