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关于此项目
经验公式(希尔记法):
C16H17N3O3S·CH3SO3H
化学文摘社编号:
分子量:
427.50
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
Quality Level
assay
≥98% (HPLC)
form
powder
color
off-white to tan
solubility
DMSO: >10 mg/mL
storage temp.
2-8°C
SMILES string
CS(O)(=O)=O.NC(=N)SCCc1ccc(OCc2ccc(cc2)[N+]([O-])=O)cc1
InChI
1S/C16H17N3O3S.CH4O3S/c17-16(18)23-10-9-12-3-7-15(8-4-12)22-11-13-1-5-14(6-2-13)19(20)21;1-5(2,3)4/h1-8H,9-11H2,(H3,17,18);1H3,(H,2,3,4)
InChI key
WGIKEBHIKKWJLG-UHFFFAOYSA-N
Biochem/physiol Actions
KB-R7943 抑制反转的 Na(+)/Ca(2+)交换剂 NCX。
KB-R7943 抑制反转的 Na(+)/Ca(2+)交换剂 NCX。在心肌细胞中,Ca2+ 在收缩过程中从胞内存储中释放出来,在舒张过程中再被吸收回胞内。NCX 是防止 Ca2+ 超载的主要机制,因为钙离子跨质膜流入。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Camille Loubiere et al.
Scientific reports, 7(1), 5040-5040 (2017-07-13)
Mitochondrial integrity is critical for the regulation of cellular energy and apoptosis. Metformin is an energy disruptor targeting complex I of the respiratory chain. We demonstrate that metformin induces endoplasmic reticulum (ER) stress, calcium release from the ER and subsequent
Ignacio Ibáñez et al.
Neurochemistry international, 123, 125-132 (2018-03-27)
GLT-1 is the main glutamate transporter in the brain and its trafficking controls its availability at the cell surface, thereby shaping glutamatergic neurotransmission under physiological and pathological conditions. Extracellular glutamate is known to trigger ubiquitin-dependent GLT-1 internalization from the surface
Reno C Reyes et al.
ASN neuro, 4(1) (2012-01-25)
Astroglial excitability operates through increases in Ca2+cyt (cytosolic Ca2+), which can lead to glutamatergic gliotransmission. In parallel fluctuations in astrocytic Na+cyt (cytosolic Na+) control metabolic neuronal-glial signalling, most notably through stimulation of lactate production, which on release from astrocytes can
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| K4144-5MG | 04061833944691 |
| K4144-25MG | 04061833944684 |