K4389
KR-32568
≥98% (HPLC), solid
别名:
[5-(2-Methyl-5-fluorophenyl)furan-2-ylcarbonyl]guanidine
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选择尺寸
关于此项目
经验公式（希尔记法）:
C13H12FN3O2
化学文摘社编号:
分子量:
261.25
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
产品名称
KR-32568, ≥98% (HPLC), solid
InChI key
DTLDHYBZLVASJQ-UHFFFAOYSA-N
SMILES string
Cc1ccc(F)cc1-c2ccc(o2)C(=O)NC(N)=N
InChI
1S/C13H12FN3O2/c1-7-2-3-8(14)6-9(7)10-4-5-11(19-10)12(18)17-13(15)16/h2-6H,1H3,(H4,15,16,17,18)
assay
≥98% (HPLC)
form
solid
color
white
solubility
DMSO: ~10 mg/mL
storage temp.
2-8°C
Quality Level
Gene Information
human ... SLC9A1(6548)
Biochem/physiol Actions
Sodium/hydrogen exchanger-1 (NHE-1) inhibitor.
Sodium/hydrogen exchanger-1 (NHE-1) inhibitor; IC50 = 0.23 μM; inhibited NHE-1-mediated rabbit platelet swelling; in anesthetized rats, reduced infarct size from 67% (control) to 43% (at 0.1 mg/kg) and 24% (at 1.0 mg/kg); reduced number of ventricular premature beats from 530 to 266 (at 0.1 mg/kg) and 115 (at 1.0 mg/kg); reduced ventricular fibrillation incidence from 17 to 8 (0.1 mg/kg) and 0 (1.0 mg/kg); implications for research and treatment of myocardial ischemic diseases.
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
10 - Combustible liquids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter
法规信息
新产品
此项目有
Daniele Torella et al.
Journal of the American Heart Association, 3(2), e000434-e000434 (2014-03-29)
Diabetes mellitus (DM) has multifactorial detrimental effects on myocardial tissue. Recently, carbonic anhydrases (CAs) have been shown to play a major role in diabetic microangiopathy but their role in the diabetic cardiomyopathy is still unknown. We obtained left ventricular samples
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