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Merck
CN

K4394

PKF118-310

≥98% (HPLC)

别名:

1,6-二甲基-嘧啶 [5,4-e]-1,2,4-三嗪-5,7 (1H,6H)-二酮, 毒性黄素, 黄丝菌素

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关于此项目

经验公式(希尔记法):
C7H7N5O2
化学文摘社编号:
分子量:
193.16
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
Assay:
≥98% (HPLC)
Form:
powder
Quality level:
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Quality Level

assay

≥98% (HPLC)

form

powder

color

white to light brown

solubility

H2O: 10 mg/mL, clear

storage temp.

2-8°C

SMILES string

CN1N=CN=C(C1=N2)C(N(C)C2=O)=O

InChI

1S/C7H7N5O2/c1-11-6(13)4-5(10-7(11)14)12(2)9-3-8-4/h3H,1-2H3

InChI key

SLGRAIAQIAUZAQ-UHFFFAOYSA-N

Biochem/physiol Actions

PKF118-310 是 Tcf4/β-连环蛋白信号通路的拮抗剂。该化合物破坏 Tcf4/β-连环蛋白复合物并抑制 Tcf4 应答基因的表达。PKF118-310 抑制肝细胞癌、结肠肿瘤和淋巴细胞白血病细胞系中生存素的表达并诱导细胞凋亡。
PKF118-310 是一种 Tcf4/β-连环蛋白拮抗剂。


pictograms

Skull and crossbones

signalword

Danger

hcodes

Hazard Classifications

Acute Tox. 2 Oral

存储类别

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

法规信息

涉药品监管产品

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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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全球贸易项目编号

货号GTIN
K4394-5MG04061833944721
K4394-25MG04061832924472