K4394
PKF118-310
≥98% (HPLC)
别名:
1,6-二甲基-嘧啶 [5,4-e]-1,2,4-三嗪-5,7 (1H,6H)-二酮, 毒性黄素, 黄丝菌素
质量水平
方案
≥98% (HPLC)
表单
powder
颜色
white to light brown
溶解性
H2O: 10 mg/mL, clear
储存温度
2-8°C
SMILES字符串
CN1N=CN=C(C1=N2)C(N(C)C2=O)=O
InChI
1S/C7H7N5O2/c1-11-6(13)4-5(10-7(11)14)12(2)9-3-8-4/h3H,1-2H3
InChI key
SLGRAIAQIAUZAQ-UHFFFAOYSA-N
生化/生理作用
PKF118-310 是 Tcf4/β-连环蛋白信号通路的拮抗剂。该化合物破坏 Tcf4/β-连环蛋白复合物并抑制 Tcf4 应答基因的表达。PKF118-310 抑制肝细胞癌、结肠肿瘤和淋巴细胞白血病细胞系中生存素的表达并诱导细胞凋亡。
PKF118-310 是一种 Tcf4/β-连环蛋白拮抗剂。
警示用语：
Danger
危险声明
危险分类
Acute Tox. 2 Oral
储存分类代码
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
涉药品监管产品
此项目有
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Yongsung Kang et al.
Scientific reports, 9(1), 11038-11038 (2019-08-01)
The activated methyl cycle (AMC) is responsible for the generation of S-adenosylmethionine (SAM), which is a substrate of N-acylhomoserine lactone (AHL) synthases. However, it is unknown whether AHL-mediated quorum sensing (QS) plays a role in the metabolic flux of the
Z Wang et al.
British journal of pharmacology, 117(2), 293-298 (1996-01-01)
1. It has been suggested that the toxic effect of toxoflavin (TXF) produced by Pseudomonas cocovenenas is mainly due to the impairment of electron transfer of the mitochondrial respiratory chain. However, the cardiovascular effect of TXF is unknown. In the
Hari S Karki et al.
PloS one, 7(9), e45376-e45376 (2012-10-03)
Burkholderia glumae is the primary causal agent of bacterial panicle blight of rice. In this study, 11 naturally avirulent and nine virulent strains of B. glumae native to the southern United States were characterized in terms of virulence in rice
Giulia Devescovi et al.
Applied and environmental microbiology, 73(15), 4950-4958 (2007-06-15)
Burkholderia glumae is an emerging rice pathogen in several areas around the world. Closely related Burkholderia species are important opportunistic human pathogens for specific groups of patients, such as patients with cystic fibrosis and patients with chronic granulomatous disease. Here
Shusheng Wang et al.
Carbohydrate research, 342(9), 1254-1260 (2007-04-07)
Eight novel toxoflavin glycosides, which are potential prodrugs in antibody directed enzyme prodrug therapy (ADEPT), were synthesized. The structures of all toxoflavin glycosides were characterized by (13)C NMR spectroscopy, elemental analysis, and MS. Their enzymatic hydrolysis activities were tested against
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