K4643
PKCθ, active, GST tagged human
PRECISIO® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution
别名:
MGC126514, MGC141919, PRKCQ, PRKCT, nPKC-theta
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关于此项目
NACRES:
NA.32
UNSPSC Code:
12352200
Specific activity:
673-911 nmol/min·mg
Assay:
≥70% (SDS-PAGE)
Recombinant:
expressed in baculovirus infected Sf9 cells
recombinant
expressed in baculovirus infected Sf9 cells
product line
PRECISIO® Kinase
assay
≥70% (SDS-PAGE)
form
buffered aqueous glycerol solution
specific activity
673-911 nmol/min·mg
mol wt
~110 kDa
UniProt accession no.
shipped in
dry ice
storage temp.
−70°C
Gene Information
human ... PRKCQ(5588)
General description
PKCθ (protein kinase C θ) is a serine/threonine kinase, belonging to protein kinase C family.
Biochem/physiol Actions
PKCθ (protein kinase C θ) is required for T cell activation and proliferation. In presence of TCR (T cell receptor) stimulation, it is responsible for activation of NF-AT (nuclear factor of activated T-cells), NF-κB (nuclear factor κ B) and AP1 (adaptor-related protein complex 1). It might be a target for the treatment of type 2 diabetes. PKCθ is needed for fat-mediated insulin resistance in skeletal muscle.
Physical form
Supplied in 50 mM Tris-HCl, pH 7.5, with 150 mM NaCl, 0.2 5mM DTT, 0.1 mM EGTA, 0.1 mM EDTA, 0.1 mM PMSF, and 25% glycerol.
Legal Information
PRECISIO is a registered trademark of Merck KGaA, Darmstadt, Germany
存储类别
10 - Combustible liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)